Covid-19 Innovation Challenges by Innoget

A Novel Therapeutic Approach Targeting Coronavirus Replication-Essential RNAs by Oligonucleotides

Posted by Covid-19 Innovation Challenges by InnogetVery responsive · Innovative Products and Technologies · United Kingdom

Summary of the technology

A Novel Therapeutic Approach Targeting Coronavirus Replication-Essential RNAs by Oligonucleotides.

The research team plans to develop a drug to inhibit human SARS-CoV-2 replication. They will use comparative genomics to detect conserved regions within the coronavirus family, and within human CoV-19 population, in order to identify essential genes that can be targeted to inhibit the virus replication.

Project ID : 47-2020-10912

Covid-19 Innovation Challenges by Innoget

Description of the technology

The research team plans to develop a drug to inhibit human SARS-CoV-2 replication. They will use comparative genomics to detect conserved regions within the coronavirus family, and within human CoV-19 population, in order to identify essential genes that can be targeted to inhibit the virus replication.

The drug will be a relevant allele-specific oligonucleotide (ASOs), to be delivered into the lung epithelial cells. Following delivery into lung cells, the ASOs will bind the virus’ essential mRNAs, activate RNAse and induce degradation of these mRNAs, and inhibit replication of the virus in the cells.

Project manager

Mel Larrosa
VP Business Development Healthcare

Project researchers

Rotem Karni
HUJI, School of Medicine - IMRIC
Biochemistry and Molecular Biology

Yuval Tabach
HUJI, School of Medicine - IMRIC
Developmental Biology and Cancer Research

Alexander Rouvinski
HUJI, School of Medicine - IMRIC
Microbiology and Molecular Genetics

Technology Owner

Covid-19 Innovation Challenges by Innoget

Innovation Intermediary

Related keywords

  • Biological Sciences
  • Virus, Virology / Antibiotics / Bacteriology
  • Infectious Diseases
  • Genetic Engineering / Molecular Biology
  • Recombinant DNA
  • Industrial genetic engineering applications
  • Covid-19

About Covid-19 Innovation Challenges by Innoget

Innovation Intermediary from United Kingdom

Ahead of the current Coronavirus outbreak, Innoget is fully committed to contributing to mobilizing scientific and expert communities to find a real solution to the Covid-19 pandemic. Therefore, we're supporting worldwide calls and programs that could help in any aspects of the coronavirus crisis.

Is your organization promoting or looking for innovation or research initiatives to mitigate the Covid-19 outbreak? Email us at covid19@innoget.com to list them.

Channeled through Innoget's online open innovation network, initiatives in the health, virology, medicine, or novel technologies applied to human health, among others, are listed and disseminated to Innoget members -ranging from hospitals, research institutes, scientists, businesses, and public administrations- and innovation partners worldwide.

Technology Offers on Innoget are directly posted and managed by its members as well as evaluation of requests for information. Innoget is the trusted open innovation and science network aimed at directly connect industry needs with professionals online.