Yissum - Research Development Company of the Hebrew University

Applying Organically Doped Copper to Filters and Surfaces to Act as Antiviral Agents

Posted by Yissum - Research Development Company of the Hebrew UniversityResponsive · Innovative Products and Technologies · Israel

Summary of the technology

The Avnir and Hayouka labs have been working together over the past few years, with the aim of developing novel copper composites that are resistant to pathogenic bacteria and are based on a new family of materials that Avnir has termed “organically doped metals” (organics@metal). These hybrid materials combine two very different chemical families —metals and any organic molecules — which have a synergetic effect in various applications, including biological and medical ones. The general approach for the preparation of the metallic composites involves a room-temperature, one-pot, reduction of the metal cation (its positively charged ions) in the presence of the desired organic molecule while using carefully selected reducing agents. Using this approach, the team has developed novel antimicrobial-doped copper in which antimicrobial peptides or small antibacterial molecules are entrapped. It has demonstrated the new materials’ high efficacy both in vitro and as a novel crop protection agent in plants.
Prof. Avnir and Dr. Hayouka will expand their current study to develop efficient copper-based antiviral agents. They will explore the entrapment of various active agents, which have been suggested as capable of tackling HCoV-19. The designed compounds will be tested on HCoV-19. The researchers are negotiating to conduct the tests in China. They are also exploring the potential of converting the compounds into a product with an Israeli start-up specializing in nanometric copper.

Project ID : 47-2020-10885

Yissum - Research Development Company of the Hebrew University

Description of the technology

Recently published research studied the aerosol and surface stability of HCoV-19, the novel human coronavirus that emerged in China in late 2019 and triggered the current pandemic. According to the study’s findings, HCoV-19 remained most stable on plastic and stainless steel, with the viable virus still detectible up to 72 hours after application. Interestingly, no viable virus could be measured after just four hours on a copper surface. Since contaminated surfaces may cause severe infection, these findings are highly significant for the battle against HCoV-19.

The Avnir and Hayouka labs have been working together over the past few years, with the aim of developing novel copper composites that are resistant to pathogenic bacteria and are based on a new family of materials that Avnir has termed “organically doped metals” (organics@metal). These hybrid materials combine two very different chemical families —metals and any organic molecules — which have a synergetic effect in various applications, including biological and medical ones. The general approach for the preparation of the metallic composites involves a room-temperature, one-pot, reduction of the metal cation (its positively charged ions) in the presence of the desired organic molecule while using carefully selected reducing agents. Using this approach, the team has developed novel antimicrobial-doped copper in which antimicrobial peptides or small antibacterial molecules are entrapped. It has demonstrated the new materials’ high efficacy both in vitro and as a novel crop protection agent in plants.

Prof. Avnir and Dr. Hayouka will expand their current study to develop efficient copper-based antiviral agents. They will explore the entrapment of various active agents, which have been suggested as capable of tackling HCoV-19. The designed compounds will be tested on HCoV-19. The researchers are negotiating to conduct the tests in China. They are also exploring the potential of converting the compounds into a product with an Israeli start-up specializing in nanometric copper

Project manager

Ilya Pittel
VP, BD AGTECH, FOODTECH, VETERINARY & ENVIRONMENT

Project researchers

David Avnir
HUJI, Faculty of Science
The Institute of Chemistry

Saul Burdman
HUJI, Faculty of Agricultural, Food and Environmental Quality Sciences
Plant Pathology and Microbiology

Zvi Hayouka
HUJI, Faculty of Agricultural, Food and Environmental Quality Sciences
Biochemistry, Food Science and Nutrition

Related keywords

  • Virus, Virology / Antibiotics / Bacteriology
  • Surface treatment (painting, galvano, polishing, CVD, PVD)
  • Coatings
  • Infectious Diseases
  • Covid-19
  • covid-19

About Yissum - Research Development Company of the Hebrew University

Technology Transfer Office from Israel

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Founded in 1964 to protect and commercialize the Hebrew University’s intellectual property. Ranked among the top technology transfer companies, Yissum has registered over 8,900 patents covering 2,500 inventions; has licensed out 800 technologies and has spun-off 90 companies. Products that are based on Hebrew University technologies and were commercialized by Yissum generate today over $2 Billion in annual sales.

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