Enhanced Secretion of Proteins by Tag-Cleaving Cellular System
Enhanced Secretion of Proteins by Tag-Cleaving Cellular System Project ID : 6-2019-8747
Enhanced Secretion of Proteins by Tag-Cleaving Cellular System/technology-offers/7710/enhanced-secretion-of-proteins-by-tag-cleaving-cellular-system
Posted by Yissum - Research Development Company of the Hebrew UniversityResponsive2020-01-17 17:17:34 · Innovative Products and Technologies · Israel
Summary of the technology
Enhanced Secretion of Proteins by Tag-Cleaving Cellular System
Project ID : 6-2019-8747
Description of the technology
Protein Secretion is a fundamental aspect in production of therapeutic proteins in eukaryotic cells. Most therapeutic proteins are produced as secreted proteins in mammalian cells such as CHO and HEK293. An essential milestone in the production scheme is the amount of produced protein, since it will affect the cost of production. Low productivity will often result in high production costs, where insufficient secretion might prevent the therapeutic application of biologics since it is not cost-effective.
Our invention proposes a novel method for improving production of secreted proteins by using stable cell lines in combination with specific cloning expression vectors in eukaryotic cells. Such a method will reduce costs and increase productivity of numerous recombinant and therapeutic proteins.
Project manager
Mel Larrosa
VP Business Development Healthcare
Project researchers
Tsafi Danieli
HUJI, Faculty of Science
The Wolfson Foundation Centre for Applied Structural Biology
Related keywords
About Yissum - Research Development Company of the Hebrew University
Technology Transfer Office from Israel
Yissum - Research Development Company of the Hebrew UniversityYissum Research Development Company of the Hebrew University of Jerusalem Ltd. Founded in 1964 to protect and commercialize the Hebrew University’s intellectual property. Ranked among the top technology transfer companies, Yissum has registered over 8,900 patents covering 2,500 inventions; has licensed out 800 technologies and has spun-off 90 companies. Products that are based on Hebrew University technologies and were commercialized by Yissum generate today over $2 Billion in annual sales.
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