Enhanced Secretion of Proteins by Tag-Cleaving Cellular System

Summary of the technology

Enhanced Secretion of Proteins by Tag-Cleaving Cellular System
Project ID : 6-2019-8747

Details of the Technology Offer

Protein Secretion is a fundamental aspect in production of therapeutic proteins in eukaryotic cells. Most therapeutic proteins are produced as secreted proteins in mammalian cells such as CHO and HEK293. An essential milestone in the production scheme is the amount of produced protein, since it will affect the cost of production. Low productivity will often result in high production costs, where insufficient secretion might prevent the therapeutic application of biologics since it is not cost-effective.

Our invention proposes a novel method for improving production of secreted proteins by using stable cell lines in combination with specific cloning expression vectors in eukaryotic cells. Such a method will reduce costs and increase productivity of numerous recombinant and therapeutic proteins.

Project manager

Mel Larrosa
VP Business Development Healthcare

Project researchers

Tsafi Danieli
HUJI, Faculty of Science
The Wolfson Foundation Centre for Applied Structural Biology

Related Keywords

  • Medicine, Human Health
  • Biology / Biotechnology
  • Genome Research
  • Micro- and Nanotechnology related to Biological sciences
  • Recombinant DNA
  • Monoclonal Antibodies and Hybridomas
  • Gene Splicing and Manufacturing Equipment
  • Other Genetic Engineering
  • Molecular design Market
  • Microbiology Market
  • Micro- and Nanotechnology related to Biological sciences
  • Biochemistry / Biophysics Market
  • Toxicology Market
  • In vitro Testing, Trials Market
  • Stem cells and biobanks
  • Cellular and Molecular Biology Market
  • Population genetics Market
  • Gene Expression, Proteom Research Market
  • Bioinformatics Market
  • Enzymology/Protein Engineering/Fermentation
  • Genetic Engineering Market
  • Diagnostic
  • Therapeutic
  • Other Medical/Health Related
  • Agro and Marine biotech
  • Anatomy, Pathology, Immunology, Physiology
  • Clinical Medicine
  • Life Science & Biotechnology
  • Peptide / Protein

About Yissum - Research Development Company of the Hebrew University

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Founded in 1964 to protect and commercialize the Hebrew University’s intellectual property. Ranked among the top technology transfer companies, Yissum has registered over 8,900 patents covering 2,500 inventions; has licensed out 800 technologies and has spun-off 90 companies. Products that are based on Hebrew University technologies and were commercialized by Yissum generate today over $2 Billion in annual sales.

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