Non–invasive method for the objective assessment of the intraocular scattering of the cornea and the crystaline lens

Summary of the technology

A new method has been developed for the assessment of the intraocular scattering generated in each structure of the human eye, i.e., the cornea and the crystalline lens. Based on a non-invasive recording of images of the light reflected on the different surfaces of the eye (Purkinje images) and their posterior image processing allows the objective assessment of the intraocular scattering of the cornea and the crystalline lens separately. It is a simple and cost-effective method easy to use in clinics.

Universitat Politècnica de Catalunya - UPC
Universitat Politècnica de Catalunya - UPC
Universitat Politècnica de Catalunya - UPC
Universitat Politècnica de Catalunya - UPC

The Challenge

Retinal image quality is the first limit to human visual performance, being affected by aberrations and scattering. The contribution of the latter has a great impact since it reduces the contrast of the retinal image and produces loss of vision, which is manifested in different diseases such as cataracts and some corneal disorders. Laser refractive surgery and intraocular lenses implantation can also increase the level of scattering.
Nowadays, the most common tests used in clinical practice for the measurement of intraocular scattering are subjective, as the measurement of visual functions (Visual Acuity, Contrast Sensitivity Function) or the observation of the eye through a slit-lamp. Few instruments have been developed in the last years that allow the objective measurement of intraocular scattering as a whole, that is, that corresponding to the whole eye. Hence, there is a need for objective, non-invasive methods that permit to separate the contribution of the cornea and the crystalline lens to the overall intraocular scattering.

The Technology

The system is based on recording images of the reflection on the ocular surfaces (Purkinje Images) of the light coming from an object, preferably opaque, which includes areas that allow light to pass to a greater or lesser degree, so that light is received in the eye in a series of clear and dark distinct areas. The analysis of the contrast in the Purkinje images, mainly P3 (reflection on the anterior surface of the crystalline lens) and P4 (reflection on the posterior surface of the crystalline lens), allows quantifying the intraocular scattering due to both the cornea and lens. The technology is objective and non-invasive. It overcomes the limitation of just having a global evaluation of the scattering of the eye, allowing the discrimination of the contribution of the cornea and the crystalline lens.

Current stage of development

A preclinical prototype is available.

Applications and Target Market

Business opportunity for companies devoted to development of ophthalmic diagnostic equipment and ophthalmologic instrumentation.

Innovative advantages

· Assessment of the scattering due to the cornea and the crystalline lens separately
· Non-invasive and objective measurement
· Can be incorporated to an existing device as a module or implemented as a standalone instrument.

Intellectual property status

  • Granted Patent
  • Patent application number :-
  • Granted Patent
  • Patent application number :-

Related Keywords

  • Optical Materials
  • Measurement devices
  • Medicine, Human Health
  • Diagnostics, Diagnosis
  • Measurements and Standards
  • Measurement Tools
  • Optical Technology related to measurements
  • Electronic measurement systems
  • Medical/health
  • Analytical and Scientific Instrumentation
  • Medical Health related
  • Diagnostic
  • Diagnostic services
  • Medical imaging
  • Other ( Diagnostic related )
  • Other diagnostic
  • Ophthalmology, Ear, nose and throat diseases
  • Medical equipment
  • Medical instruments
  • Diagnostic equipment
  • Laboratory equipment
  • Equipment and instrumentation
  • health technologies
  • non-invasive measurements
  • ophtalmic
  • ophtalmic diagnostic

About Universitat Politècnica de Catalunya - UPC

The Universitat Politècnica de Catalunya - BarcelonaTech is a public institution dedicated to higher education and research in the fields of engineering, architecture and science, which contributes its knowledge and expertise in order to increase scientific output, transfer its results to society and provide a network of scientific and technical state-of-the-art facilities and technology valorization services that place us at the leading edge of innovation and economic development.

The UPC has established itself as a driver of innovation and is the technology partner of choice for companies and organizations with which it develops projects and builds partnerships. A role borne out by the numerous agreements and research projects that have been set in motion by groups, organizations and laboratories; the creation of new technology-based companies; the generation and exploitation of patents, and the scientific and technical services UPC makes available to its environment in order to generate progress and employment.

The Technology Transfer Office (SGI) is responsible of Designing, coordinating and implementing research valorisation strategies, carrying out the protection policy of the research results, marketing these results through license contracts and designing and setting up the University's enterprise creation model in order to transfer the results of the research to the market, protect and commercialize these results, promote the culture of entrepreneurship and innovation, and create technology-based companies within the UPC environment.

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