A new system for the assessment of the tear film quality and the diagnosis of dry-eye has been developed. Based on a non-invasive recording of images of the light reflected on the tear-film of the eye, posterior image processing allows the objective assessment of dry-eye. It’s a simple and cost-effective system easy to use in clinics.
The Challenge
Dry-eye disease (DED) is prevalent among 14.5% of the population worldwide (17.9% in women and 10.% in men), which is expected to increase in developed countries with continuous aging.
Dry eye occurs when the tear film which protects the ocular surface is injured and its normal function is disturbed. This multifactorial disease of the tear film and ocular surface results in symptoms of discomfort, visual disturbance, and instability with potential damage to the ocular surface.
There is an increasing difficulty in diagnosing the severity of the condition, as there are not too many modalities to diagnose it, the most common tests used in clinical practice for the diagnosis of dry-eye are either subjective, as questionnaires or invasive as the assessment of the stability of tear film orits break-up time.
In recent years great efforts have been made to develop objective and non-invasive methods for dry-eye analysis based on new technologies such as corneal topography, These methods are based in expensive instrumentation with the consequent impact in the cost of the tests for the patients.
The Technology
The system is based on recording images of the light reflected in the tear film of the eye. When blinking is prevented, dry-spots appear in the tear film, which cause in the images the presence of diffraction, interference, and phase change effects, due to the hole itself, and speckle, due to the exposure of the corneal epithelium. These phenomena can be quantified by means of a fast imaging processing algorithm based on identifying the existence of different structures in the images.
The technology is non-invasive and allows the assessment of tear film quality and the diagnosis of dry-eye objectively and at a low-cost. It is a potential candidate to become a gold standard in dry eye care.
Innovative advantages
Current development status
Working prototypes: A preclinical prototype is available
Desired business relationship
Patent licensing
Technology development
Intellectual property status
Patent already applied for
Applications and Target Market
Business opportunity for companies devoted to the development of ophthalmic diagnostic equipment and ophthalmologic instrumentation.
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