Yissum - Research Development Company of the Hebrew University

Early Detection and Personalized Treatment of Breast Cancer, Using Comparative Genomics

Posted by Yissum - Research Development Company of the Hebrew UniversityResponsive · Innovative Products and Technologies · Israel

Summary of the technology

Using cutting-edge comparative genomics, data integration and machine learning, the researchers will develop a comprehensive gene panel that can identify increased risk of breast cancer and offer personalized treatment options based on PARP inhibitors
Project ID : 6-2018-6690

Description of the technology

Prof. Levy-Lahad Ephrat – Director of the Medical Genetics Institute at Shaare Zedek Hospital, Jerusalem

Category

LifeSciences and BioTechnology

Computer Science

Keywords

AI, Artificial Intelligence, Machine Learning, Digital Health, Personalized Medicine, Oncology, Breast cancer, Data Integration

Current development stage

General list: TRL4 Technology validated in lab

Application

  • Breast cancer is the most common cancer among women.
  • In >70% of cases with suspected hereditary, no mutations could be found in the known susceptibility genes (BRCA1, BRCA2, PALB2, etc.).
  • Establishing a comprehensive panel that identifies the driver of mutations in patients is of particular importance for personalized risk assessment, prevention and treatment of breast cancer.

Technology

Using cutting-edge comparative genomics, data integration and machine learning, we will develop a comprehensive gene panel that can identify an increased risk of breast cancer and offer personalized treatment options based on PARP inhibitors.

Our Innovation

We aim to develop a platform for predicting the risk for hereditary breast cancer in significantly more patients and offer personalized drug treatment based on the identified mutations.

Breast cancer patient:

  • Identify the causative mutations
  • Optimize and guide treatments

Woman at risk:

  • Risk predictor
  • Optimized treatments(PARPi)

Project manager

Mel Larrosa
VP Business Development Healthcare

Project researchers

Yuval Tabach
HUJI, School of Medicine - IMRIC
Developmental Biology and Cancer Research

Related keywords

  • Information Processing, Information System, Workflow Management
  • IT and Telematics Applications
  • Medicine, Human Health
  • Biology / Biotechnology
  • Genome Research
  • Micro- and Nanotechnology related to Biological sciences
  • Cytology, Cancerology, Oncology
  • Bioinformatics Technology
  • Computers
  • Computer Graphics Related
  • Specialised Turnkey Systems
  • Scanning Related
  • Peripherals
  • Computer Services
  • Computer Software Market
  • Other Computer Related
  • Recombinant DNA
  • Monoclonal Antibodies and Hybridomas
  • Gene Splicing and Manufacturing Equipment
  • Other Genetic Engineering
  • Molecular design Market
  • Microbiology Market
  • Micro- and Nanotechnology related to Biological sciences
  • Biochemistry / Biophysics Market
  • Toxicology Market
  • In vitro Testing, Trials Market
  • Stem cells and biobanks
  • Cellular and Molecular Biology Market
  • Population genetics Market
  • Gene Expression, Proteom Research Market
  • Bioinformatics Market
  • Enzymology/Protein Engineering/Fermentation
  • Genetic Engineering Market
  • Diagnostic
  • Therapeutic
  • Other Medical/Health Related
  • Anatomy, Pathology, Immunology, Physiology
  • Clinical Medicine
  • Life Science & Biotechnology
  • Oncology / Cancer

About Yissum - Research Development Company of the Hebrew University

Technology Transfer Office from Israel

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Founded in 1964 to protect and commercialize the Hebrew University’s intellectual property. Ranked among the top technology transfer companies, Yissum has registered over 8,900 patents covering 2,500 inventions; has licensed out 800 technologies and has spun-off 90 companies. Products that are based on Hebrew University technologies and were commercialized by Yissum generate today over $2 Billion in annual sales.

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