Yissum - Research Development Company of the Hebrew University

Transgenic Plants with Enhanced Resistance to Plant Pathogens

Posted by Yissum - Research Development Company of the Hebrew UniversityResponsive · Innovative Products and Technologies · Israel

Summary of the technology

Demonstrates genetic constructs and amino acid sequences conferring resistance to plant pathogens
Project ID : 8-2006-330

Yissum - Research Development Company of the Hebrew University

Description of the technology

Transgenic Plants with Increased Resistance to Common Pathogens


Agriculture, transgenic plants, amino acid sequences, pathogen resistance, Botrytis cinerea, powdery mildew Sphaerotheca fuliginea

Development Stage

Resistance to Botrytis cinerea demonstrated in a commercial crop


  • Demonstrates genetic constructs and amino acid sequences conferring resistance to plant pathogens,especially resistancetoBotrytis cinerea, Sphaerotheca fuliginea and the viruses TMV, PVY, YLCV
  • No undesired effects when consumed: Resistance achieved by transfecting plants with sequences naturally occurring in cucumber plants or homologous genes from other plants
  • Facilitates selection of pathogen-resistant plants
  • Research demonstrates that infection on the leaves of plants with increased expression of the hetrologous sequence both in-vitro and in the growth chamber was two- to three-fold higher than in control plants
  • Resistance demonstrated in tomato plants

Our Innovation

  • Transfecting plants with a naturally occurring hetrologous sequence confers resistance to many common plant pathogens and in particular Botrytis cinerea
  • With this innovation, plants will have:
  • A smaller number of infected loci
  • A smaller area of infected loci
  • A shorter infectionperiod
  • Longer delay before infection

The Opportunity

  • Plants with increased resistance to common pathogens

Development Milestones

  • To identify target commercial varieties and to generate transgenic plants with the constructs or to isolate homologous sequences and to use them as markers in breeding programs
  • To test rose and banana plants for the resistance to pathogens

Additional Information

  • Relevant research:Vainstein, A.et al. (2006) Spatial and temporal regulation of plastid lipid-associated protein CHRC supports its dual role. Plant Phys. 142:233-244.

Project manager

Amichai Baron
VP, Head of Business Development, Agritech & Envir

Project researchers

Alexander (Sasha) Vainstein
HUJI, Faculty of Agricultural, Food and Environmental Quality Sciences
Plant Sciences and Genetics

Related keywords

  • Agriculture
  • Agro chemicals
  • Agriculture, Forestry, Fishing, Animal Husbandry and Related Products
  • Agricultural genetic engineering applications
  • Agricultural chemicals
  • agriculture
  • plant genetics

About Yissum - Research Development Company of the Hebrew University

Technology Transfer Office from Israel

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Founded in 1964 to protect and commercialize the Hebrew University’s intellectual property. Ranked among the top technology transfer companies, Yissum has registered over 8,900 patents covering 2,500 inventions; has licensed out 800 technologies and has spun-off 90 companies. Products that are based on Hebrew University technologies and were commercialized by Yissum generate today over $2 Billion in annual sales.

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