Multifunctionalized nanoparticles for cancer diagnosis and treatment

  • Universidad de Granada
  • From Spain
  • Responsive
  • Patents for licensing

Summary of the technology

A synthesis method of polymeric multifunctionalized nanoparticles has been developed. These nanoparticles have different agents that offer the ability to diagnose, treat and monitor different types of cancer specifically.

Nowadays, functionalized nanoparticles are opening a wide range of opportunities to improve the diagnosis and treatment of different kind of pathologies. However, further studies are needed to optimize this nanosystem. In light of this, the present invention offers new efficient and versatile nanoparticles.

Details of the Technology Offer

-The patented nanoparticles are focussed in the integration of diagnosis and therapy in one nanodevice, so called theragnosis. This approach enables the diagnosis together with the treatment and monitoring of treatment efficiency and disease progress at the same time. These nanoparticles are conjugated with the following agents:

  • A tumour-specific ligand refers to any molecule, particularly any peptide, which is tumour-specific of the tumour to be treated or diagnosed. This ligand is conjugated to the surface of the nanoparticle.
  • An imaging trackerrefers to any agent that can be used for monitoring the efficacy of the treatment or the diagnosis.
  • Drug/s to treat the tumour.

Unlike nanoparticles for theragnostic known in the prior art, where the drug and the imaging tracker are heterogeneously encapsulated inside the particle, the controlled multi-functionalization of our nanoparticles allows tuning the ratio between the amounts of each one of the components: the drug, the ligand and the diagnostic agent. This fact increases dramatically the possibilities of developing more effective nanodevices for controlled released and monitoring in real time.

ADVANTAGES AND BENEFITS

-Multifunctional tool.The nanoparticles of the invention allow the integration into a single therapeutic agent of the following abilities:

  • Diagnosisdue to the imaging tracker.
  • Treating cancer,thanks to the therapeutic payload.
  • Monitoring the efficacy of the treatment.

-Active tumour-targeting. The tumour-specific ligand increases the retention and accumulation of nanoparticles in the tumour resulting in an efficient and selective internalization in the tumour cells. This allows:

  • Improvement in the therapeutic efficacy.
  • Reduction of anticancer drug toxicity. Administering drugs locally rather than systemically (affecting the whole body) is a common way to decrease side effects.

-Versatile therapeutic agents.The nanoparticles can diagnose and treat different types of cancer by changing the imaging tracker and the drug respectively (personalized medicine).

-Stable nanoparticles with an efficient cancer cell internalization.

Applications

Cancer treatment

Desired business relationship

Patent licensing

Intellectual property status

  • Patent already applied for
  • Patent application number :P201830360

  • Patent already applied for
  • Patent application number :PCT/ES2019/070259

Related Keywords

  • Diagnostics, Diagnosis
  • Cytology, Cancerology, Oncology
  • Pharmaceutics
  • Diagnostic
  • Diagnostic services
  • Diagnostic equipment
  • cancer
  • nanoparticles
  • treatment
  • tumor
  • theragnosis
  • active tumour-targeting
  • cancer treatment
  • cancer diagnosis

About Universidad de Granada

Granada University is one of the most important universities of Spain. The main goal is to transfer technology that our research groups, more than 500, are developing to the industries and companies which are able to take profit from them. It is a general University so Research and Development are offered in different fields like Health Science and Technology, Physics, Chemistry and Mathematics, Environment and Natural Resources, Biotechnology, Information and Communication Technologies, Social, Economic and Legal Sciences....

We hope you find technologies of your interest which will allow us working together in the near future.

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