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Consejo Superior de Investigaciones Científicas posted this:

CSIC and the University of Valencia have developed antibodies capable of determining ochratoxin A in food and ensure compliance with legislation on food products regarding the presence of this mycotoxin. Antibodies have been generated using novel functionalized derivatives of ochratoxin A. These immunoreagents have shown their efficacy in both direct and indirect competitive ELISA to detect concentrations close to parts per trillion. We are looking for companies interested in patent licensing for the development of fast, sensitive and portable kits for the analysis of ochratoxin A in foods and beverages based on these antibodies. The license of the patent is offered Effective, fast and accurate detection Ochratoxin A has a higher incidence in cereals, wine, juices and coffee One of the most harmful and frequent mycotoxins in food is ochratoxin A. Its presence is a real problem for human health due to its toxicity, and it causes significant economic losses to various productive sectors. The main fungi producing ochratoxin A belongs to the genera Penicillium and Aspergillus, and the products with the highest incidence are cereals, wine, juices and coffee. The small concentrations at which this potent toxin is usually found commonly require the use of sophisticated chromatographic methods. An alternative is the generation of antibodies against ochratoxin A with superior performance to the existing ones that allow this toxin being recognized with high affinity and specificity. These immunoreagents can be easily implemented in various analytical platforms, from the simplest, such as competitive ELISAs and immunochromatographic strips, to more complex, like chips or biosensors of different types, which allows us to simultaneously analyze a large number of samples in low-resource settings such as warehouses, cellars and even farmlands. Main applications and advantages  Ochratoxin A derivatives functionalized at new positions have been synthesized that faithfully preserve the structure and characteristics of this potent mycotoxin.  These new compounds have proven to be extremely efficient as haptens to generate antibodies capable of recognizing ochratoxin A with an affinity and selectivity not previously described.  Immunoassays developed using these immunoreagents have been shown to be very sensitive, allowing analysis of ochratoxin A at levels close to 10 parts per trillion.  These new methods are faster than instrumental procedures, especially when analyzing complex samples such as wine and coffee.  The generated immunoreagents are easily adaptable to portable methods, such as ELISA kits or immunochromatographic strips. Patent status Prioriy patent application filed suitable for international extension For more information contact with: Mª Jesus Añón Marín Instituto de Agroquímica y Tecnología de Alimentos Consejo Superior de Investigaciones Científicas (CSIC) Tel.: +34 963900022 E-mail:
Antibodies to measure residual levels of mycotoxin ochratoxin A in food

Yissum - Research Development Company of the Hebrew University posted this:

Future Meat Technologies LTD. Project ID : 26-2018-4638

Fundació URV posted this:

Gallic Acid is a naturally occurring phenolic compound that is widely distributed throughout the plant kingdom. Different studies have demonstrated the strong antioxidant, anti-inflammatory, anti-mutagenic and anticancer properties of GA, and daily intake may reduce the risk of diseases and bring health benefits. More recently, Gallic Acid has also been studied for its beneficial effects on cardiovascular diseases. It inhibits dyslipidemia, hepatosteatosis and oxidative stress in high-fat diet fed rats, protects the myocardium against isoproterenol-induced oxidative stress in rats, ameliorates the heart-function defects of myocardial dysfunction associated with streptozotocin-induced type-1 diabetic rats and exhibits anti-hyperglycemic and lipid-lowering properties in high-fat diet mice. Gallic Acid is commonly used as antioxidant by the food industry. However, until now, it is not known that the gallic acid could block the renin-angiotensin-aldosterone system (RAAS), which is the innovative aspect discover for the Nutrigenomic Group for the Gallic Acid. The inhibition of the RAAS by Gallic Acid is considered to be of special relevance because RAAS overactivity is currently associated with not only hypertension but also vascular inflammation, the development of atherosclerosis, left ventricular hypertrophy, nephrosclerosis and cardiovascular events. This discovery has a big importance because it opens a wide field of use for this compound in the food, nutraceutical or pharmaceutical industry.
Gallic Acid for the treatment of pathologies produced by hyperactivation of renin-angiotensin-aldosterone system