Foodstuffs Intended For Special Nutritional Uses Technology Offers

Fundació URV posted this:

Gallic Acid is a naturally occurring phenolic compound that is widely distributed throughout the plant kingdom. Different studies have demonstrated the strong antioxidant, anti-inflammatory, anti-mutagenic and anticancer properties of GA, and daily intake may reduce the risk of diseases and bring health benefits. More recently, Gallic Acid has also been studied for its beneficial effects on cardiovascular diseases. It inhibits dyslipidemia, hepatosteatosis and oxidative stress in high-fat diet fed rats, protects the myocardium against isoproterenol-induced oxidative stress in rats, ameliorates the heart-function defects of myocardial dysfunction associated with streptozotocin-induced type-1 diabetic rats and exhibits anti-hyperglycemic and lipid-lowering properties in high-fat diet mice. Gallic Acid is commonly used as antioxidant by the food industry. However, until now, it is not known that the gallic acid could block the renin-angiotensin-aldosterone system (RAAS), which is the innovative aspect discover for the Nutrigenomic Group for the Gallic Acid. The inhibition of the RAAS by Gallic Acid is considered to be of special relevance because RAAS overactivity is currently associated with not only hypertension but also vascular inflammation, the development of atherosclerosis, left ventricular hypertrophy, nephrosclerosis and cardiovascular events. This discovery has a big importance because it opens a wide field of use for this compound in the food, nutraceutical or pharmaceutical industry.
Gallic Acid for the treatment of pathologies produced by hyperactivation of renin-angiotensin-aldosterone system