Yissum - Research Development Company of the Hebrew University

Development of 2,4-D Resistant Non-Transgenic Solanaceae Plants

Posted by Yissum - Research Development Company of the Hebrew UniversityResponsive · Innovative Products and Technologies · Israel

Summary of the technology

Researcher used transcriptomics to identify 5 crisper/cas KO targets for generating 2,4-D resistant tomatoes
Project ID : 8-2016-4342

Description of the technology




Dichlorophenoxy acetic acid, 2,4-D, herbicide resistant, plants

Current development stage

General list: TRL2 Technology concept formulated

Collaboration Opportunity

Sponsored Research with an option to License Research Results


2,4-D is a herbicide widely used for eradicating broad leaf weeds with a worldwide market value of over $1 billion per year. Despite its success, this herbicide is not used in fields planted with dicots, such as soy, cotton, potatoes and canola. Dicot plants are extremely sensitive to 2,4-D and easily suffer from severe yield drag when exposed to drift and therefore 2,4-D is not used in fields planted with dicots.

To date, a transgenic approach can be used for imparting 2,4-D resistance in plants (both monocots and dicots), however, the path to deregulation with this transgenic approach is costly, time consuming and plant resistance to 2,4-D is negatively influenced by environmental conditions. This resistance to 2,4-D is reduced because the bacterial enzyme used for breaking down 2,4-D has a reduced efficiency in high temperatures.

Our Innovation

The researchers are developing a way for solanaceae plants of interest to resist 2,4-D herbicide. The novel method is considered a non-transgenic approach and can be used either alone or in conjunction with other known approaches which will enhance the resistance even further.


The unique proprietary approach utilizes CRISPR/CAS to prevent 2,4-D herbicide uptake into the solanaceae plant.


Our approach offers the industry a technology that is non-transgenic which may not need to go through the deregulation process. Furthermore, dicots modified by this approach will be able to benefit from the use of 2,4-D in the field.

The researchers is seeking funding for further research with an option to license the research results.

Contact in Yissum

Project manager

Ilya Pittel

Project researchers

Baruch Rubin
HUJI, Faculty of Agricultural, Food and Environmental Quality Sciences
Plant Sciences and Genetics

Assaf Mosquna
HUJI, Faculty of Agricultural, Food and Environmental Quality Sciences
Plant Sciences and Genetics

Related keywords

  • Agro chemicals
  • Agriculture
  • Agriculture and Marine Resources
  • Agriculture Machinery / Technology
  • Biocontrol
  • Crop Production
  • Pesticides
  • Precision agriculture
  • Seed coating
  • Agricultural genetic engineering applications
  • Agricultural chemicals
  • Agriculture, Forestry, Fishing, Animal Husbandry and Related Products
  • agriculture
  • Plant Protection & Bio-Control
  • Herbicides

About Yissum - Research Development Company of the Hebrew University

Technology Transfer Office from Israel

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Founded in 1964 to protect and commercialize the Hebrew University’s intellectual property. Ranked among the top technology transfer companies, Yissum has registered over 8,900 patents covering 2,500 inventions; has licensed out 800 technologies and has spun-off 90 companies. Products that are based on Hebrew University technologies and were commercialized by Yissum generate today over $2 Billion in annual sales.

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