Yissum - Research Development Company of the Hebrew University

New Method to Culture Contact-Dependent Cells in Suspension

Posted by Yissum - Research Development Company of the Hebrew UniversityResponsive · Innovative Products and Technologies · Israel

Summary of the technology

A new method for culturing contact-dependent cells in suspension
A unique cell line of chicken embryonic fibroblasts (CEFs) that can reach extremely high cell densities in suspensions, was developed using this method
Project ID : 6-2018-4673

Description of the technology


chicken embryonic fibroblasts, CEF, cell density, Human vaccines, veterinary vaccines, viral vaccines

Current development stage

TRL4 Technology validated in lab

Our Innovation

Methods and cell lines to improve density of Chicken Embryonic Fibroblasts (CEFs)

Chicken Embryonic Fibroblasts (CEFs) are commonly used in the industry, and as so, methods for improving large-scale industrial cell production are of need, specifically for vaccine production


CEF are routinely used to produce vaccines. The proposed technology can be used by pharmaceutical and biotechnology companies to develop human and veterinary viral and therapeutic vaccines. The expected increase in yield is up to 40-fold in comparison to current growing methods

The cell line is a continuous line of chicken embryo. The cells are free of endogenous sequences related to avian sarcoma and leukosis viruses and have normal fibroblastic morphology. The cells have higher proliferation rate and also can be subcultured infinite number of times

Project manager

Mel Larrosa
VP Business Development Healthcare

Project researchers

Yaakov Nahmias
HUJI, School of Computer Science and Engineering

Related keywords

  • Medicine, Human Health
  • Biology / Biotechnology
  • Genome Research
  • Micro- and Nanotechnology related to Biological sciences
  • Recombinant DNA
  • Monoclonal Antibodies and Hybridomas
  • Gene Splicing and Manufacturing Equipment
  • Other Genetic Engineering
  • Molecular design Market
  • Microbiology Market
  • Micro- and Nanotechnology related to Biological sciences
  • Biochemistry / Biophysics Market
  • Toxicology Market
  • In vitro Testing, Trials Market
  • Stem cells and biobanks
  • Cellular and Molecular Biology Market
  • Population genetics Market
  • Gene Expression, Proteom Research Market
  • Bioinformatics Market
  • Enzymology/Protein Engineering/Fermentation
  • Genetic Engineering Market
  • Diagnostic
  • Therapeutic
  • Other Medical/Health Related
  • Agro and Marine biotech
  • Anatomy, Pathology, Immunology, Physiology
  • Clinical Medicine
  • Life Science & Biotechnology
  • Research / Development tools

About Yissum - Research Development Company of the Hebrew University

Technology Transfer Office from Israel

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Founded in 1964 to protect and commercialize the Hebrew University’s intellectual property. Ranked among the top technology transfer companies, Yissum has registered over 8,900 patents covering 2,500 inventions; has licensed out 800 technologies and has spun-off 90 companies. Products that are based on Hebrew University technologies and were commercialized by Yissum generate today over $2 Billion in annual sales.

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