Biomarkers for the diagnosis and prognosis of aortic aneurysm
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Technology Offer
Biomarkers for the diagnosis and prognosis of aortic aneurysm
- CNIC from Spanish National Center for Cardiovascular Research (CNIC)
- From Spain
- Responsive
- Patents for licensing
Summary of the technology
Scientists at the Centro Nacional de Investigaciones Cardiovasculares and Centro de Biología Molecular Severo Ochoa (CBM-CSIC-UAM) have discovered that the nitric oxide (NO) pathway is overactivated in the aortas of mice and patients with Marfan Syndrome and that the activity of this pathway causes the aortic aneurysms that characterize this disease.
This discovery has important implications for patients with this syndrome, because these molecules could be used as biomarkers for disease monitoring, and we are now studying their potential as prognostic indicators.
Details of the Technology Offer
Scientists at the Centro Nacional de Investigaciones Cardiovasculares and Centro de Biología Molecular Severo Ochoa (CBM-CSIC-UAM) have discovered that the nitric oxide (NO) pathway is overactivated in the aortas of mice and patients with Marfan Syndrome and that the activity of this pathway causes the aortic aneurysms that characterize this disease.
This discovery has important implications for patients with this syndrome, because these molecules could be used as biomarkers for disease monitoring, and we are now studying their potential as prognostic indicators.
Scientific publication: https://www.nature.com/articles/s41467-021-22933-3
Intellectual property status
- Patent already applied for
- Patent application number :PCT/EP2022/060201
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About Spanish National Center for Cardiovascular Research (CNIC)
The Spanish National Center for Cardiovascular Research (CNIC) is a leading international research center dedicated to understanding the basis of cardiovascular health and disease and to translating this knowledge into improved patient care.
CNIC scientific area is organized into two departments focused on Basic Research and Clinical Research, fully interconnected through six multidisciplinary programs grouped into three research areas:
1 Vascular Pathophysiology
2 Myocardial Pathophysiology
3 Cell Developmental Biology
Our portfolio include biomarkers, genetic and diagnostic tools, animal models and treatments for cardiovascular, inflammatory and infectious diseases, among others. Some examples of our current projects include treatment for pulmonary hypertension, myeloproliferative diseases and trained immunity for prevention of infections. Regarding diagnosis, we are currently working on biomarkers for myocarditis, subclinical atherosclerosis and calcific aortic valve disease.
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