Yissum - Research Development Company of the Hebrew University

A novel spatial (non-topical) mosquito repellent using unique bio-friendly chemical compound

Posted by Yissum - Research Development Company of the Hebrew UniversityResponsive · Innovative Products and Technologies · Israel

Summary of the technology

Chemical compound (GRAS, DEET-free) to be used as spatial (non topical) mosquito repellent
Known mechanism of action

A novel spatial (non-topical) mosquito repellent, for long range based on unique chemical compound

Project ID : 8-2018-4611

Yissum - Research Development Company of the Hebrew University

Description of the technology


Chemistry & Materials , Veterinary & Animal science


Chemical compound, mosquito Olfactory system, repellent, spatial

Current development stage

TRL4 Technology validated in lab

Collaboration Opportunity

Sponsored Research with an option to License Research Results


The mosquito is the most dangerous insect on earth. No other species, including our own, is responsible for the loss of as many human lives each year as mosquitoes are. The diseases that mosquitos carry and transmit to people through bites, kill 725,000[1] annually (most from malaria).

One kiss from a female mosquito causes an unpleasant itch at best and at worst may inject into the blood stream unsavory microscopic visitors.

There are many insect repellents on the market, however, a majority of them are topical repellents, effective only for ashort range (<100 cm).

Our Innovation

A novel spatial (non-topical) mosquito repellent, for long range based on an unique chemical compound

  • Long range of action (one meter or longer)
  • High user acceptability
  • Long lasting once applied
  • Long shelf life


  • Thousands of olfactory receptors belonging to different gene families have been identified in various insect species. Each species exhibits between 60 to 400 receptor genes.
  • Using molecular methods and understanding mosquitos’ peripheral olfactory system and the situational context of their behavior a spatial mosquito repellent was developed
  • This spatial mosquito repellent is a GRAS, DEET – free stable and safe chemical compound with a known mechanism of action.
  • It is also an environmentally friendly volatile solution, that can be used in large doses.


  • Personal and area protection over a long range (>100 cm)
  • The researcher is interested in industry sponsored research funding and/or licensing of the technology.


Project manager

Ilya Pittel

Project researchers

Jonathan Bohbot
HUJI, Faculty of Agricultural, Food and Environmental Quality Sciences

Related keywords

  • Materials Technology
  • Chemistry
  • Veterinary Medicine
  • Environment
  • Clean Production / Green Technologies
  • Waste Management
  • Animal health
  • Chemicals and Materials
  • Pollution and Recycling Related
  • Chemistry & Materials
  • formulations
  • mosquito repelant

About Yissum - Research Development Company of the Hebrew University

Technology Transfer Office from Israel

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Founded in 1964 to protect and commercialize the Hebrew University’s intellectual property. Ranked among the top technology transfer companies, Yissum has registered over 8,900 patents covering 2,500 inventions; has licensed out 800 technologies and has spun-off 90 companies. Products that are based on Hebrew University technologies and were commercialized by Yissum generate today over $2 Billion in annual sales.

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