Summary of the technology
New device and apparatus for mechanical or simultaneous electromechanical stem cell cultures have been designed and patented by UPC and IGTP. The device is disposable and allows sterile mechanical stimulation on standard Petri dishes without breaking the sterile barrier. Partners to further develop the system and/or to establish commercial agreements along with technical cooperation are sought.
Cardiovascular diseases have a huge impact on population health. Heart failure is the endstage of many cardiovascular diseases, but the leading cause is the presence of a large scar due to an acute myocardial infarction. Current treatments for repairing tissue rely on achieving in vitro cardiac differentiated cells that mimic the native cardiac electromechanical cell physiology. Electrical and mechanical stimulation of stem cell cultures may help to improve their cardiac differentiation and tissue structure formation.
Current devices for electromechanical stimulation have major flaws on the use of standard laboratory sterilizing procedures.
The device presented enables combination of both electrical and mechanical stimulation either independently or simultaneously. The mechanical stimulation is performed with a non-invasive and aseptic novel approach. A sterile, single use device is placed into a standard Petri dish. The cells are seeded in a volume contained in the central area of the device, which goes through mechanical stimulation thanks to the embedded magnets and the external magnetic field.
Current stage of development
· Device, device fabrication procedure and apparatus already developed Electrical impedance spectroscopy on-line monitoring — in process
Applications and Target Market
· Tissue engineering Regenerative medicine Stem cells research Metabolic studies
· Mechanical or simultaneous electromechanical stimulation on standard Petri dishes.
The device can be fully sterilized prior cell culture seeding or may be sold directly pre-sterilized for immediate use.
The benefits of the electromechanical stimulation can be non-destructively and on line monitored using Electrical Impedance Spectroscopy.
Intellectual property status
Technology available for licensing with technical cooperation Patent Status EP / US patent application
Universitat Politècnica de Catalunya - UPC
Technology Transfer Office