Summary of the technology
The device presented enables the combination of both electrical and mechanical stimulation either independently or simultaneously.
The mechanical stimulation is performed with a non-invasive and aseptic novel approach. A sterile, single use device is placed into a standard culture plate. The cells are seeded in a volume contained in the central area of the device, which goes through mechanical stimulation thanks to the embedded magnets and the external magnetic field.
Description of the technology
Cardiovascular diseases have a huge impact on population health. Heart failure is the end-stage of many cardiovascular diseases, but the leading cause is the presence of a large scare due to an acute myocardial infaction. Current treatments for repairing tissue rely on achieving in vitro cardiac differentiated cells that mimic the native cardiac electromechanical cell physiology. Electrical and mechanical stimulation of stem cell cultures may help to improve their cardiac differentiation and tissue structure formation. Current devices for electomechanical stimulation have major flaws on the use of standard laboratory sterilizing procedures.
The invention relates to the use of a new device for mechanical and/or electrical stimulation to be used with 2D mololayer and 3D stem cells cultures for tissue engineering applications. The device is disposable and allows sterile electromechanical stimulation on standard culture plates without breaking the sterile barrier.
Main advantages of its use
- Mechanical and/or simultaneous electrical stimulation on standard culture plates.
- The benefits of the electromechanical stimulation can be non-destructively and on-line monitored using Electrical Impedance Spectroscopy.
- The device can be fully sterilized prior cell culture seeding or may be sold directly pre-sterilized for immediate use.
Additional information (attached documents)
About Germans Trias i Pujol Health Sciences Research Institute
Research Institute from SpainGermans Trias i Pujol Health Sciences Research Institute
The mission of the Health Sciences Research Institute of the “Germans Trias i Pujol” Foundation (IGTP) are to generate, preserve, disseminate and increase multidisciplinary and translational knowledge, as well as echnological development in biomedical sciences, by means of a dynamic, efficient and effective organisation.
The ultimate goal of the IGTP is to become a research centre of reference, able to transfer the generated knowledge into clinical practice and therapeutics (translationality), in order to optimise the psychophysical health and quality of life of the population.
- The IGTP, as an institution devoted to biomedical research:
- Assumes its humanitarian view, ethical principles, and solidarity, as well as the principles of sustainability in resource management and relationship with the environment.
- Its activities will be always related with the health needs of the population and the priority areas in healthcare development.
- Assumes the scientific method as its own and faces its goals by means of programs of excellence which enable the leadership in the areas of knowledge of the interest of its researchers.
- Protects the data used in, and generated by the research programmes, as well as the privacy of the patients and healthy individuals who participate in them.