Yissum - Research Development Company of the Hebrew University

A Microarray to Reveal a Histone Profile of Cells or Tissue

Posted by Yissum - Research Development Company of the Hebrew UniversityResponsive · Innovative Products and Technologies · Israel

Summary of the technology

A Microarray to Reveal a Histone Profile of Cells or Tissue
Project ID : 6-2008-2059

Description of the technology


Research/development tools, Diagnostics, Biomarkers

Development Stage

Proof of concept has been shown. Seeking collaboration for the development ofa commercial kit


Biochips currently undergoing transition from primarily research-and-development tools to applied applications in next-generation sequencing, drug discovery and development, and clinical diagnostics.


  • High throughput antibody microarray provides epigenetic profile of histone modification in cells or tissues in one go
  • Currently Western blot tests are used to determine the state of each of the dozens of different histone modifications - time consuming and labor intensive procedure
  • Uses in cancer diagnosis, to monitor cancer progress, to monitor effect of drugs on cells or tissues

Our Innovation

High-throughput antibody microarrays suitable for all available antibodies to show histone modifications in cells or tissues

The Opportunity

  • Histones have an important role in mood disorders, memory
  • Histone profile changes with cancer progression – potential for cancer diagnosis
  • Drugs that target histones (HDAC inhibitors) are a growing family of drugs that are beneficial for central nervous system disorders, neurodegenerative diseases, cancer and more. These arrays will enable efficient screening of the specific actions of novel and existing drugs.

Project manager

Shani Bullock
VP, Business Development, Healthcare

Project researchers

Eran Meshorer
HUJI, Faculty of Science
The Alexander Silberman Institute for Life Sciences

Related keywords

  • Medicine, Human Health
  • Biology / Biotechnology
  • Genome Research
  • Micro- and Nanotechnology related to Biological sciences
  • Recombinant DNA
  • Monoclonal Antibodies and Hybridomas
  • Gene Splicing and Manufacturing Equipment
  • Other Genetic Engineering
  • Molecular design Market
  • Microbiology Market
  • Micro- and Nanotechnology related to Biological sciences
  • Biochemistry / Biophysics Market
  • Toxicology Market
  • In vitro Testing, Trials Market
  • Stem cells and biobanks
  • Cellular and Molecular Biology Market
  • Population genetics Market
  • Gene Expression, Proteom Research Market
  • Bioinformatics Market
  • Enzymology/Protein Engineering/Fermentation
  • Genetic Engineering Market
  • Clinical Medicine
  • Anatomy, Pathology, Immunology, Physiology
  • Agro and Marine biotech
  • Other Medical/Health Related
  • Therapeutic
  • Diagnostic
  • Life Science & Biotechnology
  • Research / Development tools

About Yissum - Research Development Company of the Hebrew University

Technology Transfer Office from Israel

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Founded in 1964 to protect and commercialize the Hebrew University’s intellectual property. Ranked among the top technology transfer companies, Yissum has registered over 8,900 patents covering 2,500 inventions; has licensed out 800 technologies and has spun-off 90 companies. Products that are based on Hebrew University technologies and were commercialized by Yissum generate today over $2 Billion in annual sales.

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