New Liver X receptor β Targeted Library

Summary of the technology

OTAVA offers new Liver X receptor β Targeted Library which is targeted towards Liver X receptor β and comprises 436 small screening compounds.

Otava Research Institute

Details of the Technology Offer

OTAVA offers new Liver X receptor β Targeted Library ( which is targeted towards Liver X receptor β and comprises 436 small screening compounds.
Liver X receptor β (LXRβ or NR1H2) is a promising therapeutic target for lipid disorders, atherosclerosis, chronic inflammation, autoimmunity, cancer and neurodegenerative diseases. LXRs connect and regulate the expression of genes that encode proteins associated with cholesterol absorption, transport, efflux, excretion and conversion to bile acids. The identification of the LXRs and better understanding of the mechanisms by which LXR signalling regulates lipid homeostasis in different tissues (including the liver, intestine and brain), open new opportunities for therapeutic insights in human metabolism.
To design this library, we performed molecular docking of our Drug-Like Collection of compounds in crystal structure of human LXRβ (PDB ID: 1UPV). All compounds are available from stock, cherry picking is possible. To order the library, please send your request directly

Related Keywords

  • Biological Sciences
  • Biology / Biotechnology
  • Biochemistry / Biophysics Technology
  • Synthetic Biology
  • Biobased chemical building blocks

About Otava Research Institute

Otava Institute is a global provider of one-stop integrated research solutions for business and life science. Our team includes chemists, biologists, physicists whose combined efforts contribute to the complex contract research projects for pharmaceutical, agro, cosmetic and material science industries.We are dedicated to providing clients with outstanding service in these key areas and will continue to push boundaries to remain an industry front-runner. Each day we expand our core competencies delivering of new technologies to meet all the customer’s needs.

Our location in Toronto Ontario, Canada provides our clients with the added advantage of North American IP rules and regulations and secure communication and logistics. Our Ukraine – based R&D facilities represented with the Ukrainian Laboratories, that is cooperating with leading Ukrainian research institutions and carries out research work in the format of outsourcing.

We work as a preferred partner to many of the world’s top 10 pharma firms, and hundreds of other companies, providing support with creative solutions for complex technical compound issues. Our scientific knowledge, combined with our research and manufacturing capability, enables us to support chemical processing and production without ever compromising on quality.

Our experience, dedication, and commitment to quality make us an ideal partner for discovery stage research.

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