Ukrainian Laboratories

Synthesis of 1-(Aryl-1H-pyrrolyl)(phenyl)methyl-1H-imidazole Derivatives as Antiprotozoal Agents

Posted by Ukrainian LaboratoriesResponsive · Innovative Products and Technologies · Ukraine

Summary of the technology

Our company offers the chemical optimization service - synthesis of a unique 1-(aryl-1H-pyrrolyl)(phenyl)methyl-1H-imidazole derivatives for your biological projects, related to developing of antiprotozoal drugs.

Ukrainian Laboratories

Description of the technology

Trypanosomatid and plasmodium parasites are producing a great deal of chronic diseases and affecting hundreds of millions people mainly in developing countries. However, in the last years, such diseases are dramatically disseminating worldwide, due to some factors including vector and human migrations or co-infections in immunosuppressed patients. The current antiprotozoal therapies are unsatisfactory due to their low efficacy, high toxicity and appearance of resistant parasitic strains. Therefore, there is an speedy need to develop new antiprotozoal drugs.

Imidazole-based compounds show good antiprotozoal activity. Our company offers the chemical optimization service - synthesis of a unique 1-(aryl-1H-pyrrolyl)(phenyl)methyl-1H-imidazole derivatives for your biological projects, related to developing of antiprotozoal drugs. These novel compounds could be selected from a set of 5,000+ exclusive virtual 1-(aryl-1H-pyrrolyl)(phenyl)methyl-1H-imidazoles using our company’s proprietary molecular modeling platform ODDA™.

This set of novel 1-(aryl-1H-pyrrolyl)(phenyl)methyl-1H-imidazole derivatives will be synthesized exclusively upon your request.

A recent paper from the Journal of Medicinal Chemistry* showed that authors designed and synthesized a series of imidazole-based compounds structurally related to an antiprotozoal agent with nanomolar activity which they identified recently. Most of these analogs possess micromolar activities against T. b. rhodesiense and L. donovani, nanomolar – against P. falciparum and low nanomolar – against T. cruzi.

Technology Owner

Ukrainian Laboratories

Research & Technology Organization

Related keywords

  • Biological Sciences
  • Biology / Biotechnology
  • Cellular and Molecular Biology Technology
  • Medical Health related
  • Other Medical/Health Related
  • Pharmaceuticals/fine chemicals
  • trypanosomatid and plasmodium parasites

About Ukrainian Laboratories

Research & Technology Organization from Ukraine

Otava Institute is a global provider of one-stop integrated research solutions for business and life science. Our team includes chemists, biologists, physicists whose combined efforts contribute to the complex contract research projects for pharmaceutical, agro, cosmetic and material science industries.We are dedicated to providing clients with outstanding service in these key areas and will continue to push boundaries to remain an industry front-runner. Each day we expand our core competencies delivering of new technologies to meet all the customer’s needs.

Our location in Toronto Ontario, Canada provides our clients with the added advantage of North American IP rules and regulations and secure communication and logistics. Our Ukraine – based R&D facilities represented with the Ukrainian Laboratories, that is cooperating with leading Ukrainian research institutions and carries out research work in the format of outsourcing.

We work as a preferred partner to many of the world’s top 10 pharma firms, and hundreds of other companies, providing support with creative solutions for complex technical compound issues. Our scientific knowledge, combined with our research and manufacturing capability, enables us to support chemical processing and production without ever compromising on quality.

Our experience, dedication, and commitment to quality make us an ideal partner for discovery stage research.

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