The invention relates to the development of an in vitro method for diagnosing colorectal cancer and advanced adenomas in asymptomatic individuals, by means of a test in a human biofluid, preferably serum. It consists in the joint quantification of sCD26 and NDKA proteins by specific immunoassays, and the percentage of methylation of the NEUROG1 gene by means of real-time PCR specific for methylation. The combination of the three markers by multivariate logistic regression will result in a calculated risk score for colorectal cancer or advanced adenomas, which is compared to an established cut-off point. If the test is positive, a confirmatory colonoscopy is recommended. On the contrary, if the result is negative, it is recommended to repeat the test in one year.
Applications
The invention fits within the healthcare field, specifically in digestive oncology. This non-invasive method is a very useful tool for the diagnosis of colorectal cancer and advanced adenomas in screening programs of asymptomatic individuals.
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