The invention relates to the field of retinoid X receptor (RXR) signalling and a novel vitamin A pathway called Vitamin A5 pathway. Compounds which are useful to provide (R) 9-cis-13,14-dihydro-retinoic acid an endogenous RXR ligand are claimed as well as their uses and method for preparation thereof.
The inventors identified a series of compounds including members of an independent new vitamin A pathway (Vitamin A5), most notably 9-cis-13,14-dihydroretinol (9cDHROL), and which are precursors of the actual endogenous RXR ligand. They have also surprisingly found that these precursors produce an unexpectedly high increase of 9cDHRA in the brain and are useful vectors to target brain signaling of RXRs.
The compounds of the invention are useful for pharmaceutical and nutritional uses.
Applications
Nutritional usage: nutritional or dietary supplement with the benefit of preventing, reversing and/or reducing memory loss Pharmaceutical usage: in depression, neurodegenerative and metabolic diseases, skin- and immunological diseases (including inflammation) as well as cardiovascular diseases.
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