The Challenge
A new a method for in situ self-assembling of NPs with phenolic-shell and biopolymers with nucleophilic groups into multifunctional nanocomposite hydrogel for enhancing wound closure and tissue recovery.
The Challenge
Chemically crosslinked hydrogel networks are formed by non-reversible covalent bonds between the polymer chains. Generally, this crosslinking is achieved by redox reactions, radical polymerisation, photo-polymerisation, click chemistry, Michael addition, Schiff’s base reactions or enzymes. In spite of showing good mechanical performance for a wide range of applications, the utilization of toxic catalysts or crosslinkers, and harsh conditions is a major drawback that makes them unsuitable for biomedical applications. The selfassembling occurs under mild conditions, avoiding the use of harsh chemicals and thereby is suitable for a preparation of materials with wide range of medical applications. Selfassembled hydrogels demonstrate high biocompatibility and can be explored for the in situ incorporation of bioactive agents and cells within the matrix. Up to date, most of the selfassembled hydrogels possess poor mechanical properties, slow self-healing properties or require costly and hardly scalable synthesis of the components, which have limited their application in biomedical engineering.
The Technology
Current stage of development
Laboratory validation. It’s required a pre-clinical validation.
Applications and Target Market
Fast self-assessment (Rapid Diagnostic Kit) / Point-of-care (PoC) tests for infection in out -hospital conditions, performed by patients suffering from:
Innovative advantages
· SKinGEL answers the unmet need for efficient multifunctional skin care materials to improve patients’ quality of life.
· SKinGEL is a (bio)nanotechnology-embedded skin care product providing a holistic therapeutic approach towards healthy skin.
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