Covid-19 Innovation Challenges by Innoget

Viral RNA-dependent RNA Polymerases

Posted by Covid-19 Innovation Challenges by InnogetVery responsive · Innovative Products and Technologies · United Kingdom

Summary of the technology

Viral RNA-dependent RNA Polymerases (RdRPs) Targeted Library (1259 compounds) with predicted activity against viral RdRPs is offered. It has been carefully designed using machine learning (artificial neural networks and Bayesian statistics

Covid-19 Innovation Challenges by Innoget

Description of the technology

Otava Research Institute group offers Viral RNA-dependent RNA Polymerases (RdRPs) Targeted Library (1259 compounds) with predicted activity against viral RdRPs. RNA-dependent RNA polymerase (RdRP, RDR or RNA replicase) is an catalyst of the replication of RNA from an RNA template. RdRPs are important targets for antiviral drug development. 1706 compounds with known activity against RdRP viruses (different strains of hepatitis C virus, hepatitis GB virus, influenza A virus, influenza B virus and human poliovirus 1) were randomly divided into two equal groups.

Each group had equal amounts of active and inactive compounds and was used as a training and test kit. We used a number of different molecular descriptors - topological descriptors, fingerprints, molecular weight, the number of acceptors and donors of hydrogen, the number of rings, the number of rotating bonds, LogP, PSA and others. Test kits were used to validate all variants. The best compounds selected by machine learning methods are visually analyzed. The use of 14 different artificial neural networks and models should increase the number of active compounds detected during screening.

Technology Owner

Covid-19 Innovation Challenges by Innoget

Innovation Intermediary

Related keywords

  • Pharmaceutics
  • Biological Sciences
  • Medicine, Human Health
  • Diagnostics, Diagnosis
  • Pharmaceutical Products / Drugs
  • Virus, Virology / Antibiotics / Bacteriology
  • Biology / Biotechnology
  • Molecular design Technology
  • Enzyme Technology
  • Industrial Biotechnology
  • Infectious Diseases
  • Medical Health related
  • Diagnostic
  • Pharmaceuticals/fine chemicals
  • Consumer related
  • library
  • compounds
  • machine learning
  • rna
  • rna-dependent
  • polymerases
  • library compounds

About Covid-19 Innovation Challenges by Innoget

Innovation Intermediary from United Kingdom

Ahead of the current Coronavirus outbreak, Innoget is fully committed to contributing to mobilizing scientific and expert communities to find a real solution to the Covid-19 pandemic. Therefore, we're supporting worldwide calls and programs that could help in any aspects of the coronavirus crisis.

Is your organization promoting or looking for innovation or research initiatives to mitigate the Covid-19 outbreak? Email us at covid19@innoget.com to list them.

Channeled through Innoget's online open innovation network, initiatives in the health, virology, medicine, or novel technologies applied to human health, among others, are listed and disseminated to Innoget members -ranging from hospitals, research institutes, scientists, businesses, and public administrations- and innovation partners worldwide.

Technology Offers on Innoget are directly posted and managed by its members as well as evaluation of requests for information. Innoget is the trusted open innovation and science network aimed at directly connect industry needs with professionals online.