SARS-CoV-2 Papain-like ProteaseTargeted Library

Summary of the technology

Using receptor based virtual screening OtavaResearchInstitute’s team designed the SARS-CoV-2 Papain-like Protease PLpro Targeted Library, which is contain 1058 stock compounds with predicted activity against this protease and ready for delivery.

Otava Research Institute

Details of the Technology Offer

The papain-like protease PLpro is required for coronaviral replication as a part of NSP3 multi-domain protein. The ubiquitin and ISG15 PLpro are removed from the host cell proteins to prevent coronaviruses the formation of innate immune reactions. OtavaResearchInstitute’s team designed the SARS-CoV-2 Papain-like Protease PLpro Targeted Library (1058 stock compounds) using receptor based virtual screening.
The designed SARS-CoV-2 Papain-like Protease Targeted Library comprises only druglike compounds without PAINS compounds. The library is intended for screening projects to find new compounds with activity against SARS-CoV-2.
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Related Keywords

  • Biological Sciences
  • Medicine, Human Health
  • Biostatistics, Epidemiology
  • Virus, Virology / Antibiotics / Bacteriology
  • Infectious Diseases
  • Human vaccines
  • Biology / Biotechnology
  • Applications for Health
  • Medical Health related
  • Diagnostic
  • Diagnostic services
  • Medical/health
  • Covid-19
  • coronavirus
  • sars-cov-2
  • compounds

About Otava Research Institute

Otava Institute is a global provider of one-stop integrated research solutions for business and life science. Our team includes chemists, biologists, physicists whose combined efforts contribute to the complex contract research projects for pharmaceutical, agro, cosmetic and material science industries.We are dedicated to providing clients with outstanding service in these key areas and will continue to push boundaries to remain an industry front-runner. Each day we expand our core competencies delivering of new technologies to meet all the customer’s needs.

Our location in Toronto Ontario, Canada provides our clients with the added advantage of North American IP rules and regulations and secure communication and logistics. Our Ukraine – based R&D facilities represented with the Ukrainian Laboratories, that is cooperating with leading Ukrainian research institutions and carries out research work in the format of outsourcing.

We work as a preferred partner to many of the world’s top 10 pharma firms, and hundreds of other companies, providing support with creative solutions for complex technical compound issues. Our scientific knowledge, combined with our research and manufacturing capability, enables us to support chemical processing and production without ever compromising on quality.

Our experience, dedication, and commitment to quality make us an ideal partner for discovery stage research.

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