SARS-CoV-2 Helicase Targeted Library

Summary of the technology

The offer SARS-CoV-2 Helicase (NSP13) Targeted Library, which contain 1170 compounds with predicted activity against this vital protein. The overall procedure included accurate flexible docking of Drug-like Green Collection into helicase active site.

Covid-19 Innovation Challenges by Innoget

Details of the Technology Offer

We offer a target library of SARS-CoV-2 Helicase (NSP13), which contains 1170 compounds with predicted activity on helicase SARS-CoV-2 (non-structural protein 13, NSP13), which is important for coronavirus replication. It separates double-stranded RNA (dsRNA). The identification of small molecules for which the replication apparatus is a target has shown the highest potential for the detection of antiviral drugs.

The library was developed based on virtual screening receptors using a homologous model of SARS-CoV-2 NSP13. Final selection of compounds was performed based on key structural determinants of the enzymatic active site for ligand binding, scoring, and intermolecular hydrogen bonds with key amino acid residues of the active site.

Related Keywords

  • Applications for Health
  • Biological Sciences
  • Medicine, Human Health
  • Biostatistics, Epidemiology
  • Diagnostics, Diagnosis
  • Medical Research
  • Human vaccines
  • Emergency Medicine Technology
  • Genetic Engineering Technology
  • Infectious Diseases
  • Medical/health
  • Genetic Engineering / Molecular Biology
  • Genetic Engineering Market
  • Medical Health related
  • Diagnostic
  • Diagnostic services
  • Covid-19
  • compounds
  • coronavirus
  • sars-cov-2

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