Yissum - Research Development Company of the Hebrew University

Screening of Drugs to Inhibit Viral Infections

Posted by Yissum - Research Development Company of the Hebrew UniversityResponsive · Innovative Products and Technologies · Israel

Summary of the technology

Screening of Drugs to Inhibit Viral Infections
Project ID : 47-2020-10879

Yissum - Research Development Company of the Hebrew University

Description of the technology

  • Our group has published a lot of work on the SARS Coronavirus. We were the first to characterize an important protein in the virus that has a very unusual structure and sequence (E protein). Moreover, this protein was unique to SARS and was not found in any other Coronavirus. Now importantly, the new 2019 Coronavirus has a very similar protein!
  • Researches shown that the SARS protein may impact the membrane stability due to membrane hydrophobic mismatch. It may also be an ion channel. This is good news since ion channels make very good drug targets. We have already cloned the protein from the 2019 coronavirus and showed that it is an ion channel as well. After that, we will make use of several different assays that we have developed to screen for drugs that may inhibit this channel and consequently the virus.

Project manager

Mel Larrosa
VP Business Development Healthcare

Project researchers

Isaiah Arkin
HUJI, Faculty of Science
The Alexander Silberman Institute for Life Sciences

Related keywords

  • Virus, Virology / Antibiotics / Bacteriology
  • Infectious Diseases
  • Biological Sciences
  • Covid-19
  • Genetic Engineering / Molecular Biology
  • covid-19
  • screening

About Yissum - Research Development Company of the Hebrew University

Technology Transfer Office from Israel

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Founded in 1964 to protect and commercialize the Hebrew University’s intellectual property. Ranked among the top technology transfer companies, Yissum has registered over 8,900 patents covering 2,500 inventions; has licensed out 800 technologies and has spun-off 90 companies. Products that are based on Hebrew University technologies and were commercialized by Yissum generate today over $2 Billion in annual sales.

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