Ukrainian Laboratories

Synthesis of dual-targeted inhibitors of HDAC1 and mTOR for cancer therapy

Posted by Nadiia from Ukrainian LaboratoriesResponsive · Innovative Products and Technologies · Ukraine

Summary of the technology

Our offer is a chemical optimization service - synthesis of two-target specific set of pyrazolo[3,4-d]pyrimidine derivatives as dual-targeted inhibitors of HDAC1 and mTOR. We will synthesize these novel analogs only upon your request.

Description of the technology

Histone deacetylase 1 (HDAC1, GON-10, HD1, RPD3, RPD3L1, KDAC1) is vital to regulate eukaryotic gene expression. It was shown in a number of reports that HDAC1 is regarded as one of the most perspective targets for cancer therapy.

The mechanistic target of rapamycin (mTOR, mammalian target of rapamycin, FK506-binding protein 12-rapamycin-associated protein 1, FRAP, FRAP1, FRAP2, RAFT1, RAPT1, SKS) is a serine/threonine protein kinase regulating various cellular processes - cell growth, cell proliferation, cell survival, protein synthesis, autophagy, transcription and other. mTOR is overactivated in a number of tumors.

Our offer is a chemical optimization service - synthesis of two-target specific set of pyrazolo[3,4-d]pyrimidine derivatives as dual-targeted inhibitors of HDAC1 and mTOR. These new compounds will be identified out of a range of 2,000+ virtual pyrazolo[3,4-d]pyrimidines through our company’s proprietary molecular modeling platform that is synthesized and provided for your biological projects.

We will synthesize these novel analogs only upon your request.

Compound l ((R)-N-(4-(1-(7-(Hydroxyamino)-7-oxoheptyl)-4-morpholino-1Hpyrazolo[3,4-d]pyrimidin-6-yl)phenyl)-2-methylmorpholine-4-carboxamide) proves the optimal inhibition activities against HDAC1 and mTOR.

Technology Owner

Ukrainian Laboratories

Research & Technology Organization

Related keywords

  • Biological Sciences
  • Medicine, Human Health
  • Cytology, Cancerology, Oncology
  • Biology / Biotechnology
  • Cellular and Molecular Biology Technology
  • Molecular design Technology
  • Chemical Technology and Engineering
  • Gene - DNA Therapy
  • Medical Research
  • Medical Technology / Biomedical Engineering
  • Diagnostics, Diagnosis
  • Chemicals and Materials
  • Medical/health
  • Medical Health related
  • Clinical Medicine
  • Oncology
  • Therapeutic
  • compounds
  • dual-targeted inhibitors
  • cancer therapy

About Ukrainian Laboratories

Research & Technology Organization from Ukraine

Otava Institute is a global provider of one-stop integrated research solutions for business and life science. Our team includes chemists, biologists, physicists whose combined efforts contribute to the complex contract research projects for pharmaceutical, agro, cosmetic and material science industries.We are dedicated to providing clients with outstanding service in these key areas and will continue to push boundaries to remain an industry front-runner. Each day we expand our core competencies delivering of new technologies to meet all the customer’s needs.

Our location in Toronto Ontario, Canada provides our clients with the added advantage of North American IP rules and regulations and secure communication and logistics. Our Ukraine – based R&D facilities represented with the Ukrainian Laboratories, that is cooperating with leading Ukrainian research institutions and carries out research work in the format of outsourcing.

We work as a preferred partner to many of the world’s top 10 pharma firms, and hundreds of other companies, providing support with creative solutions for complex technical compound issues. Our scientific knowledge, combined with our research and manufacturing capability, enables us to support chemical processing and production without ever compromising on quality.

Our experience, dedication, and commitment to quality make us an ideal partner for discovery stage research.

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