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Thyroid Hormone Action Indicator Transgenic Mouse: the in vivo model to promote thyroid hormone-related R&D

Posted by Laser Consult Ltd.Responsive · Patents for licensing · Hungary

Summary of the technology

A Hungarian academic research institute developed a Thyroid Hormone Action Indicator (THAI) Mouse, a transgenic mouse model to measure the authentic thyroid hormone signalling in a live animal. They are looking for potential partners that would be interested in licensing the THAI mouse model. The target users are companies developing thyromimetics.

Laser Consult Ltd.

Description of the technology

Obesity and metabolic disorders represent a huge social burden, therefore development of drugs against these problems are of great interest. The very beneficial metabolic effects to decrease body weight and cholesterol levels cannot be exploited in euthyroid patients due to unwanted, e.g. cardiac side effects of thyroid hormone. Thyroid hormone (TH) is a fundamental regulator of metabolism and cell proliferation and its level is subjected to tissue-specific regulation. This development is based on a thyroid hormone-dependent expression of a luciferase reporter protein. THAI represents the first mammalian model for tissue-specific assessment of TH action using an intact machinery of TH metabolism and signalling. THAI mouse also allows the assessment of TH action in live mammals for the first time using in vivo imaging facilitating time series studies and testing of different compounds/doses in the same animal. It was generated using a transposase-mediated approach that allowed the insertion of a single copy of the transgene into the genome that allow quantitative measurements and stable maintenance of the line without segregation of the transgenic cassette.

The attached picture Live imaging of TH action in THAI mouse. In vivo imaging on hypothyroid, euthyroid and T3-treated (1 μg/g bw i.p.) mice followed by i.p. luciferin injection. (arrow on upper panel: brown adipose tissue; circle on lower panel: intestine).

TECHNOLOGY ADVANTAGES:

  1. The TH action in the THAI mouse is determined by the fully endogenous set of regulators of thyroid hormone action including thyroid hormone receptors isoforms and their coregulators, the thyroid hormone activating and inactivating deiodinase enzymes and thyroid hormone transporters;
  2. It allows the detection of tissue-specific TH action in live animals,
  3. It can distinguish between thyroid hormone receptor isoform mediated effects.

THAI has been successfully used

  1. to study the cold-induced regulation of TH action in the brown adipose tissue, an important target of obesity research;
  2. to test the in vivo efficiency of a thyroid hormone isoform specific compound;
  3. to study tissue hypothyroidism and
  4. to asses thyroid hormone action in microdissected brain samples.

POTENTIAL APPLICATIONS AND POTENTIAL CUSTOMERS:

THAI mouse provides an excellent in vivo model for pharmaceutical companies aim to develop thyromimetic drugs for tissue-specific TH action or companies running exploratory studies for future drug development. Tissue- or TH receptor isoform specificity of new TH agonist/antagonist compounds could be tested with the help of the THAI mouse. These compounds could impact obesity and cholesterol level: that is a significant market.

THE PROPOSED BUSINESS MODEL:

They are primarily interested in the licensing of THAI mouse. They do not exclude the option to start a start-up company, but they would do it only in the presence of significant industrial interest for the invention.

Intellectual property status

Patent already applied for
US20170325429A1
United States

Technology Owner

Laser Consult Ltd.

Innovation Intermediary

Related keywords

  • Biological Sciences
  • Medicine, Human Health
  • Clinical Research, Trials
  • Genetic Engineering / Molecular Biology
  • Cellular and Molecular Biology Market
  • Medical Health related
  • Clinical Medicine
  • Endocrinology
  • thyroid hormone

About Laser Consult Ltd.

Innovation Intermediary from Hungary

Laser Consult Technical, Scientific and Economic Consulting Kft. (Ltd.) was established in 1992 with the objective of accompanying its clients from the innovational idea all the way to selling the intellectual product by providing complex innovational services.

Our mission, through our services, is to promote the utilisation of intellectual products, create a business value from innovative solutions, promote the co-operation of places of research and enterprises and the development of Hungarian higher education through the professional support of innovational activities. The foundation of the successful operation of the company is our fundamental philosophy, in which we lay a significant emphasis on establishing a relationship of confidence and developing a long-term successful co-operation with our clients.

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