Yissum - Research Development Company of the Hebrew University

A Novel Blood Test to Diagnose Disease and its Origins through Identification of Cell Free DNA

Posted by Yissum - Research Development Company of the Hebrew UniversityResponsive · Innovative Products and Technologies · Israel

Summary of the technology

Liquid Biopsy
A diagnostic two-pronged approach to interrogate epigenetic modifications in cfDNA The assay simultaneously measures cfDNA methylation and covalent histone modifications of circulating nucleosomes, and develop analysis methods for inferring the rate of cell death, physiological state, and transcriptionally active pathways in originating tissues
Keywords: Diagnosis, cell free DNA diagnosis, circulating DNA, liquid biopsies, methylation patterns, histone modification pattern, tissue of origin detection, cancer diagnosis, drug monitoring
Digital Health
Project ID : 6-2017-4530

Description of the technology


cell free DNA diagnosis, liquid biopsies, methylation patterns, histone modification

Current development stage

TRL3 - hypothesis testing and intial POC demonstrated in limited # of in-vitro models


The existing sequence methods don't enable personal cheap screening in blood for developing diseases.

Multiplexing diagnosis of epigenetics and mutations is separated from other liquid biopsies.

Currently, there is no technology for broad detection of any pathological condition at unbiased, low cost manner that can be joined with other diagnosis

Our Innovation

A novel approach interrogates epigenetic modification in cfDNA.

  • Unbiased detection of any pathological stage without a priori looking to diseases (good for screening).
  • Gives multiple information on many physiological parameters of the subject.
  • A very small sample of plasma is required.
  • Sample not chemically damaged. It can be used for further diagnosis tests and be combined with existing diagnosis.


  • Detects broad pathological sites such as multiple sclerosis, cancer and Type 2 Diabetes at low cost.
  • A novel new approach for liquid biopsy diagnosis in cancer and other diseases.
  • Personalized Medicine treatment monitoring.

Project manager

Shani Bullock
VP, Business Development, Healthcare

Project researchers

Nir Friedman
HUJI, Faculty of Science
The Alexander Silberman Institute for Life Sciences

HUJI, Faculty of Science

Related keywords

  • Medicine, Human Health
  • Biology / Biotechnology
  • Genome Research
  • Micro- and Nanotechnology related to Biological sciences
  • Recombinant DNA
  • Monoclonal Antibodies and Hybridomas
  • Gene Splicing and Manufacturing Equipment
  • Other Genetic Engineering
  • Molecular design Market
  • Microbiology Market
  • Micro- and Nanotechnology related to Biological sciences
  • Biochemistry / Biophysics Market
  • Toxicology Market
  • In vitro Testing, Trials Market
  • Stem cells and biobanks
  • Cellular and Molecular Biology Market
  • Population genetics Market
  • Gene Expression, Proteom Research Market
  • Bioinformatics Market
  • Enzymology/Protein Engineering/Fermentation
  • Genetic Engineering Market
  • Diagnostic
  • Therapeutic
  • Other Medical/Health Related
  • Agro and Marine biotech
  • Anatomy, Pathology, Immunology, Physiology
  • Clinical Medicine
  • Life Science & Biotechnology
  • Oncology / Cancer

About Yissum - Research Development Company of the Hebrew University

Technology Transfer Office from Israel

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Founded in 1964 to protect and commercialize the Hebrew University’s intellectual property. Ranked among the top technology transfer companies, Yissum has registered over 8,900 patents covering 2,500 inventions; has licensed out 800 technologies and has spun-off 90 companies. Products that are based on Hebrew University technologies and were commercialized by Yissum generate today over $2 Billion in annual sales.

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