Hydrogel hybrid material for the reconstruction of bone defects

Summary of the technology

The subject of the offer is an injectable, hydrogel hybrid material that can be used to construct a bioactive cell scaffold of a minimal invasivity. This scaffold may be located in place of a bone defect thus enabling reconstruction of bone tissue.
Application: in tissue engineering for the reconstruction of orthopedic and dental bone defects.

Jagiellonian University

Details of the Technology Offer

The observed in recent years progress in the development of tissue engineering and related sciences, focused on research on the possibilities of bone tissue reconstruction, is a response to the progressive aging process of the population, the consequences of irregular and too fast lifestyle (obesity, diabetes) and the growing number of unfortunate accidents. The interest in tissue engineering arises from the limitations of the methods used as of yet (tissue grafts, surgical reconstructions). The main problems in this regard are the insufficient amount of available tissues and organs in relation to the demand and the frequent lack of tissue and geometric biocompatibility of the materials. In addition, in the case of some injuries, the only chance for tissue regeneration is the previous implementation of so-called tissue scaffolding in the place of the cavity.

The answer to the demand for tissue engineering is presented with a biodegradable, bioactive biopolymer material that provides acceleration of the biomineralization process. The present material is a biomatrix convenient for colonization by osteoblastic cells. It can be used as an injectable scaffold, which may be introduced into the defect in the tissue in the form of a viscous sol undergoing the process of gelling in situ under physiological conditions at a proper rate controlled by its composition.

The vital advantages of the technology:

  • Structural stability of hybrid materials while maintaining the injectable form of the biopolymer sol (new synthesis method allows the elimination of the problem of potential phase separation of functionalized silica particles embedded in the biopolymer network and their uncontrolled diffusion into tissues in vivo);
  • Bioactivity of hybrid materials (the scaffolding material is a biomatrix able to integrate with the natural bone - studies were carried out under conditions simulating human SBF plasma);
  • Rapid process of the biomineralization (up to 7 days);
  • Preservation of biocompatibility, the ability to support adhesion, proliferation, and maintenance of the osteoblastic cell phenotype MG-63 (supporting the regeneration of bone defects).

The offered solution is a subject of a patent. Further development of the invention is conducted by the scientific staff of the Faculty of Chemistry of the Jagiellonian University. Currently, the Centre for Technology Transfer CITTRU is looking for entities interested in licensing and application of the technology described above.

Intellectual property status

Patent already applied for

Patent application number : P 428993 (21.02.2019)

Where :

Related Keywords

  • Materials Technology
  • Hybrid materials
  • Chemical Technology and Engineering
  • Agro chemicals
  • Organic Substances
  • Organic Chemistry
  • Biological Sciences
  • Medical Technology / Biomedical Engineering
  • Medical Biomaterials
  • Biology / Biotechnology
  • Cellular and Molecular Biology Technology
  • Biobased chemical building blocks
  • Biopolymers
  • Chemical material testing
  • Cellular and Molecular Biology Market
  • Pacemakers and artificial organs
  • Chemicals and Materials
  • Membranes and membrane-based products
  • tissue engineering
  • dental bone defect
  • bioactive cell scaffold

About Jagiellonian University

Jagiellonian University, founded 1364, is the oldest university in Poland and one of the oldest worldwide. The research and teaching activities are conducted at 15 faculties, including the Medical College (Collegium Medicum). Over 3,700 researchers work at the university and the total number of students is about 50,000.

Radoslaw Rudz

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