Yissum - Research Development Company of the Hebrew University

Novel Compounds for the Treatment of Obesity and reducing Glucose Levels

Posted by Yissum - Research Development Company of the Hebrew UniversityResponsive · Innovative Products and Technologies · Israel

Summary of the technology

Small molecule
Project ID : 6-2008-1996

Yousef Najajreh, Al Quds University


  • A growing number of peoples worldwide are suffering from the health consequences of obesity.
  • As for today, Only one drug is currently approved for long-treatment of obesity-the lipase inhibitor Xenical. Use of this product has been limited by side effects.

Our Innovation

  • The patent is covering Novel Active Compounds –derivatives of fatty acids and amino acids which may regulate feeding and body weight.
  • Compound X (the leading compound) and its derivatives represent novel compounds for the treatment of obesity which do not act on either CB1, TRPV1 or PPAR-α receptors (tested by MSD for receptor bindingactivity).
  • The compounds present new mechanisms of action (via POMC, NPY or FAAH (Fatty Acid Amide Hydrolase) inhibition in relation to known compounds on the market: Xenical (Lipase inhibition), Reductil (NE-5HT re-uptake inhibitor) and Rimonobant (CB1 receptor antagonist) (removed recently from the market).


  • Patent on new compounds which are small natural, organic molecules.
  • The Compounds are made of natural products which may be given orally and act in a dose-dependent manner.
  • Three (3) compounds improve also cognitive function as well3 compounds reduced glucose level.
  • No toxicity was found following in-vivo experiments in mice, detecting survival, neurological score and liver histopathology.
  • There is a clear opportunity for an effective and well-tolerated anti-obesity drugs. Weight loss continued for 31 days after cessation of treatment and then leveled off.
  • Non toxic.

Project manager

Mel Larrosa
VP Business Development Healthcare

Project researchers

Jehoshua Katzhendler Z"L
HUJI, School of Medicine - IMRIC
School of Pharmacy- Institute for Drug Research

Elliot Berry
HUJI, School of Medicine - IMRIC
School of Public Health

Yosefa Avraham
HUJI, School of Medicine - IMRIC
School of Public Health

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About Yissum - Research Development Company of the Hebrew University

Technology Transfer Office from Israel

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Founded in 1964 to protect and commercialize the Hebrew University’s intellectual property. Ranked among the top technology transfer companies, Yissum has registered over 8,900 patents covering 2,500 inventions; has licensed out 800 technologies and has spun-off 90 companies. Products that are based on Hebrew University technologies and were commercialized by Yissum generate today over $2 Billion in annual sales.

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