Northeastern University's Center for Research Innovation

Rapid Gas-Phase Isotopic Labeling for Enhanced Detection of Protein Conformations

Posted by Northeastern University's Center for Research InnovationResponsive · Innovative Products and Technologies · United States

Summary of the technology

Several prior-art techniques such as ion mobility spectrometry and gas-phase HDX measurements have been used for assessing the conformational properties of gaseous protein ions. Most of these approaches comprise the use of ion traps or ICR cells where a gas is introduced and the ions are incubated with the gas. However, such approaches are associated with potential limitations such as extended gas-phase labeling time, complex exchange kinetics, and comparatively low gas pressure. This novel approach enables a rapid gas-phase isotopic labeling of protein ions for enhanced detection of protein conformations.

Description of the technology

Value Proposition

The approach:

•Involves use of a curtain labeling technique wherein the protein ions are allowed to pass through a cloud of deuterated gas for labeling

•Allows for an effective control over gas-phase labeling time along with obtaining higher operational gas pressure as compared to conventional techniques

•Offers unique advantages and flexibility for analytical measurements over prior-art approaches

•Would be commercially useful for determination of protein stoichiometry along with architecturing of large functional protein assemblies

Intellectual Property status

Pending Utility Application 13/264,574

Pending Canada National Application 2,758,917

Pending European National Application 10765098.8

License status 

Available for license

Direct Link:http://neu.technologypublisher.com/technology/20052

Related keywords

  • Chemistry
  • Other
  • Chemistry
  • detection

About Northeastern University's Center for Research Innovation

Small and Medium Enterprise from United States

Northeastern University is a private national research university located in Boston, Massachusetts. Northeastern is a leader in worldwide experiential learning, urban engagement, and interdisciplinary research that meets global and societal needs. The University offers a comprehensive range of undergraduate and graduate programs leading to degrees through the doctorate in nine colleges and schools. Areas of technology research and development range across the Life Sciences and Material Sciences.

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