Mimetic polypeptides for COVID-19 prevention, treatment and diagnosis

  • Universidad de Granada
  • From Spain
  • Responsive
  • Patents for licensing

Summary of the technology

New polypeptides to prevent, treat and diagnose SARS-CoV-2 coronavirus infection have been developed. These are short sequences that mimic fragments of the HR1 region, highly conserved, and that have a high affinity for HR2, being able to inhibit the fusion of viral and cellular membranes. They are ideal components for developing new vaccines, treatments and diagnostic methods.

Universidad de Granada

Details of the Technology Offer

Coronavirus SARS-CoV-2 disease (COVID-19) has become the most severe pandemic in the last decades, causing huge human and economic losses. Despite the high research activity around it, the immunity granted by current vaccines decreases after several months, and new variants of the virus constantly appear that escape vaccine protection. In addition, no antiviral drugs exist to treat the infection.

Current vaccines are based in immunization with the complete inactivated virus; with the complete spike protein (S) using vectors, RNA or DNA with or without mutations; or with the receptor binding domain (RBD), from the S1 subunit of the spike protein. However, S1 regions are more variable than the S2 subunit, which is conserved even between different coronaviruses, and not so many mechanisms aimed at neutralizing it are currently known.

The S2 subunit features two regions HR1 and HR2 which interact during cellular and viral membranes fusion process. This subunit is homologous to transmembrane gp41 subunit from VIH, which is already demonstrated as an effective target to neutralize this virus.

Taking advantage of the high conservation of S1 subunit and its homology with gp41 subunit from VIH, new mimetic polypeptides from the HR1 region of the S2 subunit have been developed. Those polypeptides allow to block membrane fusion with SARS-CoV-2 by interfering in the conformational change of HR1 and HR2 during this process.

These HR1 mimetic polypeptides show a high thermal stability, are highly soluble and can form high-affinity complexes with HR2. Their characteristics are ideal to prevent, treat and diagnose the infection caused by these coronavirus.


  • Long-term and wide spectre immunity. Thanks to the use of a highly conserved region both in time and between variants.
  • Useful for the prevention, treatment and diagnosis. Polypeptides can be used to make vaccines, to develop treatments that block membrane fusion, and to detect antibodies against the virus inside the organism.
  • High thermal stability and high solubility of polypeptides.
  • Already tested and used mechanism against virus with homologous structures, such as VIH, against which a strong infection block is achieved.

Current development status

Experimental technologies






Desired business relationship

Patent licensing

Intellectual property status

  • Patent already applied for
  • Patent application number :P202230188

Related Keywords

  • Biological Sciences
  • Diagnostics, Diagnosis
  • Biology / Biotechnology
  • Cellular and Molecular Biology Technology
  • Molecular design Technology
  • Infectious Diseases
  • Covid-19
  • treatment
  • prevention
  • sars-cov-2
  • mimetic polypeptide

About Universidad de Granada

Granada University is one of the most important universities of Spain. The main goal is to transfer technology that our research groups, more than 500, are developing to the industries and companies which are able to take profit from them. It is a general University so Research and Development are offered in different fields like Health Science and Technology, Physics, Chemistry and Mathematics, Environment and Natural Resources, Biotechnology, Information and Communication Technologies, Social, Economic and Legal Sciences....

We hope you find technologies of your interest which will allow us working together in the near future.

Universidad de Granada

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