Biomedicine and Biotechnology Center - Leipzig University

Peptide for Titanium and Biomaterial Surface Coating for Enhanced Osseointegration

Posted by Biomedicine and Biotechnology Center - Leipzig UniversityResponsive · Patents for licensing · Germany

Summary of the technology

Our research involves the modification of a recently patented molecule that contains L-3,4-dihydroxyphenylalanine (DOPA) and other bonding peptides to increase osseointegration on metal surfaces, particularly titanium. Lab results show that when coated with this molecule, titanium surfaces showed increased signs of bio-compatibility, which is backed up by published scientific research. The technology has the potential of improving osteosynthesis and orthopedic implants, as well as many other types of surgical implants. The BBZ is looking for licensing, joint R&D, or ownership opportunities regarding this technology.

Biomedicine and Biotechnology Center - Leipzig University

Description of the technology

Cell adhesion on biologically-compatible materials is considered essential for long-term implant biocompatibility. Our research involves the modification of a recently patented molecule that contains L-3,4-dihydroxyphenylalanine (DOPA) and other bonding peptides to increase osseointegration on metal surfaces, particularly titanium. Lab results have been encouraging: when coated with this molecule, titanium surfaces showed increased cell counts, survival rates, and overall health compared to non-treated surfaces. Furthermore, the peptide showed outstanding stability in aqueous solutions. This is backed up by published research attached to this offer. Attached is additional information regarding our technology offer.

The technology offers the following advantages:

  • Effective, modified molecule for the improvement of the osseointegration of implants, reducing the risk of implant migration, inflammation, or loosening.
  • Excellent binding of the proteins to metal surfaces, in particular titanium
  • Very good peptide stability in aqueous solution
  • Coating may be enhanced with other substances

Applications

Development of more bio-compatible surgical implants or medical devices where osseointegration is a key aspect of implantation success. Examples include dental, orthopedic, and spine implants, which are typically made using bio-compatible materials such as titanium.

Current development status

Experimental technologies

Desired business relationship

Technology selling

Patent licensing

Technology development

Other

Intellectual property status

Patent already applied for
US20190241614A1
United States

Technology Owner

Biomedicine and Biotechnology Center - Leipzig University

Technology Transfer Office

Additional information (attached documents)

Related keywords

  • Coatings
  • Biological Sciences
  • Medicine, Human Health
  • Dentristry / Odontology, Stomatology Technology
  • Medical Technology / Biomedical Engineering
  • Medical Biomaterials
  • Materials Technology
  • Surgery
  • Surgical implants
  • Orthopaedics
  • Surgical instrumentation and equipment
  • Medical instruments
  • Surgical instrumentation and equipment related to Therapeutics
  • Medical equipment
  • Medical Health related
  • medical devices
  • bio-compatible materials

About Biomedicine and Biotechnology Center - Leipzig University

Technology Transfer Office from Germany

The Centre for Biotechnology and Biomedicine (BBZ) was founded in 2003 as the central research institute of the Leipzig University.
The BBZ promotes the networking of research within the university while simultaneously utilizing emerging interdisciplinary synergies. In cooperation with biotechnologically relevant groups in a life-science network at the Leipzig University, it has been possible to promote the outstanding development in biotechnology with national and international visibility and competitiveness.
Knowledge- and experience-intensive areas of innovation are for the biotechnology industry in Leipzig of great importance. In addition to high-level applied and fundamental research, the BBZ has successfully established an internationally competitive development and implementation platform. Due to its competence and capacity, the BBZ also provides technological consultation for research and industry partners.

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