Summary of the technology
The research group in «Dendrimers for biomedical applications» of the University of Alcalá presents carbosilane dendrimers with a polyphenolic nucleus, its obtaining procedure and its uses as antiviral, antibacterial and antifungal agents.
The group seeks to reach collaboration agreements, licensing or commercial agreements with technical assistance, with companies from the biotechnology, pharmaceutical and biomedicine sectors in general.
Description of the technology
The present invention relates to highly branched macromolecules, synthesized from a polyphenolic nucleus, called dendrimers, of carbosilane structure and functionalized in their periphery with anionic groups that give the macromolecule a negative net charge. In addition, the invention relates to its method of obtaining and its uses in biomedicine.
By "carbosilane dendrimer" refers in the present invention to a very branched macromolecule with a spherical shape, where the growth core of the dendrimer is a polyfunctional, in this case the nucleus is a polyphenol, the units, branches or branches of growth have skeleton carbosilane and the outer layer, surface or periphery of the dendrimer incorporates functional groups.
In addition, this dendrimer can be anionic, forming the carboxylate, phosphonate or sulfonate groups. Therefore, the present invention not only includes the dendrimers themselves, but any of their salts, for example, alkali metal or alkaline earth metal salts, which may be selected from sodium, potassium or calcium salts, preferably the salts are of sodium.
The dendrimers of the invention can have application in different fields of biomedicine, among which include its use as therapeutic, antiviral, antibacterial or antiprionic agents. In addition to their microbicidal activity, they also have anti-inflammatory activity, making them improve their prophylactic properties since the probability of infection against HIV increases significantly in the presence of inflammatory processes.
The ability of dendrimers to interfere in the virus-cell interaction suggests that they could act as topical microbicides, that is, compounds applied to the vaginal or rectal mucosa to prevent sexually transmitted diseases.
As antiviral, the dendrimer of the invention, of nanoscopic size, prevents the correct process of adhesion to the target cell, as well as the infection of this and its corresponding production of new viral particles.
It is also possible to use the dendrimers of the invention as vehicles for transporting molecules, preferably molecules with pharmacological activity (active principles), and more preferably molecules with positive charge.
Current development status
Antiviral, antibacterial and antifungal agents. (Biomedicine, Biotechnology, Health Science, Pharma, Chemistry)
Desired business relationship
Intellectual property status
Universidad de Alcalá-OTRI
Research & Technology Organization