Alpha-Integrum, Ltd.

Fermenter Tool software to improve fermentation processes

Posted by Sergey from Alpha-Integrum, Ltd.Responsive · Research Services and Capabilities · Russian Federation

Summary of the technology

Fermenter Tool software will help you solve the following tasks:
a. modeling of your fermentation process data;
b. predicting of the optimal processes;
c. detecting of the limiting substrates according to 'a' and then to do all the calculations to achieve forecasts 'b'.

Alpha-Integrum, Ltd.

Description of the technology

We offer a new software for your fermentation. This is the analytical software based on new theory, which is described in the article in the attached file. This is a promo video to the software:


English:" rel="nofollow" target="_blank">https://www.youtube.com/watch?v=gEAZXP8R2yI


Russian:" rel="nofollow" target="_blank">https://www.youtube.com/watch?v=uMw0Q3VI_wY


You could find more details here:http://fermentertool.com/en/


One of the main provisions in our experience could be formulated as: any biosynthesis involves in fact two processes - "positive " and " negative ". We assume that metabolites are synthesized only by proliferating cells. Non-proliferating cells, as a rule, destroy these products. Therefore, the signs of the constants for metabolite synthesis and degradation are opposite. The same should be stated for any substrates utilized for cell construction. All these can give a "separation" of these two processes and make recommendations to increase economic efficiency.


Our mathematical model gives to physiological similarity of cultures in different volumes, as a criterion for different scale up procedures. This similarity is equal (or close) to ratio between of the dividing cells and non-dividing cells numbers for two (three, etc.) various volumes, which will be compared between each other: 10 liters, 1 cubic meter, etc. This indicator is marked with "R" in our articles.


Our software will help you solve the following tasks:
a. modeling of your fermentation process data;
b. predicting of the optimal processes;
c. detecting of the limiting substrates according to 'a' and then to do all the calculations to achieve forecasts 'b'.


This is an unique software. Now I'm sending some materials and test calculations for different biomass, products, substrates (including C, N, P, Mg, S). The software is appropriate for calculations of all S-shaped curves for all batch processes.
You could be registered here:
http://fermentertool.com/tool/


Please, don't forget to confirm your registration when the corresponding letter will be delivered to you. (This letter may be in the "Spam", so you need to check all the folders in your e-mail address.) For testing, we offer 1 free attempts for calculations (only biomass or biomass+ (P+S)- up to 10 for both of each).


If you will want more free attempts, it can be discussed. Please, bear in mind that the deadline to submit our reports on our calculations in the test period is limited from 1-2 hours to 2 days, because some automatic functions are disabled.

Here's the address for PayPal payments: payment@fermentertool.com
The price is US$ 40 for 1 calculation. (Payment for use of the time account will be introduced after the end of the test period.)

Please note:
1) The data for the biomass should be as S- shaped curves (!)
2) The software minimal quantity of dots for the Biomass,X=f(t), should be equal no less than 8 (~4 dots for Exponential Phase of the growth curve and ~4 dots for Slow Phase.)
3) The stationary growth phase has a little significance for our software. If you have doubts about your data, please, check them through charting in the Excel programm.

We hope for mutually beneficial cooperation and we would be grateful if you keep this information confidential until we are done with the final release of software.

Yours faithfully,
Sergey Klykov, PhD

Short description of how tool can be used

Dear colleague Bhattacharya,Sourish, I would like to help you when using our software for fermentation. 1) Enter your login and password. 2) Select the button, which is necessary for calculations. This can be "Calculations for biomass" or "Calculations of biomass and product"; the last button will do the calculations also for substrates. You should remember that our software can work only with concentrations data. For biomass: g/l, billions of cells/ml, a.u./ml. 3) Enter into the left column the values of the time of cultivation, into the right one the values of biomass. If you have done the selection buttons Calculations of biomass and product", you can enter the values of products and substrates after biomass in the field, which lies on right from the biomass column. For one of biomass you can make putting up to 10 values of different substrates (e.g., sources of carbon, nitrogen, phosphorus, magnesium, etc.) and up to 10 different values of products (e.g., penicillin and/or penicillin biosynthesis related products). 4) Push "Send" button, when the procedure of entering of your data was completed; and you will be waiting for the Report in your Inbox for your emails during from 1-2 hours to 1-2 days, because the software can not be included at any time of the day. Please note: 1) The data for the biomass should be as S- shaped curves (!) 2) The software minimal quantity of dots for the Biomass,X=f(t), should be equal no less than 8 , (~4 dots for Exponential Phase of the growth curve and ~4 dots for Slow Phase.) 3) The stationary growth phase has a little significance for our software. If you have doubts about your data, please, check them through charting in the Excel programm.

Technology Owner

Alpha-Integrum, Ltd.

Innovation Intermediary

Sergey Klykov

Innovation Consultant at Alpha-Integrum, Ltd.

Additional information (attached documents)

Related keywords

  • Industrial Technologies
  • Physical Sciences and Exact Sciences
  • Biological Sciences
  • Agriculture and Marine Resources
  • Agrofood Industry
  • Medical Health related
  • Industrial Products

About Alpha-Integrum, Ltd.

Innovation Intermediary from Russian Federation

We are a team of programmers/mathematicians , which deals with calculations of microbial processes in order to improve their effectiveness.

The program is designed for engineers and scientists in the microbiological industry and R&D areas for planning, analysis and control of the fermentations, as well as for undergraduate and graduate students who are trained in the microbiological field.

An Integrated Mathematical Model of Development (IMMD) is the basis of these calculations. The IMMD have 3 basic paradigms.

Russian Federation Patent # 2228352:

For biomass:

dnXdiv/d((Xst))n= {(K/A2) ∗ [(−1)(n−1)]*n!} / [(Xst)(n+1)]− C, (1);

For product(substrates):

dP(or − S)/dτ = kdiv(for P and-S)Xdiv + kst(for P and -S)Xst, (2).

Please, see http://iopscience.iop.org/1758-5090/3/4/045006

For each separate phase we must have separate equations.
The physiological processes occurring in proliferating and stable (non-proliferating) cells differ greatly and are diametrically opposed. We assume that metabolites are synthesized only by proliferating cells. Nonproliferating cells, as a rule, destroy these products. Therefore, signs of the constants for metabolite synthesis and degradation are opposite. The same should be stated for substrates utilized for cell construction.

Our equations describe all the known diversity of the processes with S-like growth curves and changes in the concentrations of substances in closed systems, which is an entirely new and previously unknown fact. It is known that a physical law means a generalization of a numerical relationship between the objects of the real physical world that is running under specified conditions for the class of the objects and does not follow from any of the previously discovered laws. There is no reason not to admit the two described equations for the GIP as laws for GIP.

The data obtained were used for the selection of techniques to increase the protein expression by genetically modified microorganisms.

Also, this software version allows you to calculate the energy indicators of the population:

a - is a trophic factor;
m - is specific an energy consumption for maintenance of life;
f - is a consumption of an energy substrate for building of cells bodies.

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