Summary of the technology
ERTFLOW is a technology development unit from the Institute of Chemical Research of Catalonia (ICIQ), generated by the know-how produced by the research group of Prof. Miquel Pericàs, to develop and implement technical solutions in process intensification.
Our goal is to develop propietary technologies related to catalysis and flow chemistry and offering products and services to the fine chemical, pharmaceutical and biotechnological industries for the production of new products with high added value and guide them in the paradigm change from batch to flow.
Description of the technology
Which Is the Problem to Be Solved ?
Batch processing, the most usual production scheme in the pharmaceutical and fine chemicals industries, presents important disadvantages:
- Low intensification
- Waste generation
- Risks associated to large volumes
- Problems in scale-up
Flow Processing as a Convenient Alternative
From the microfluidic to the mesofluidic scale, flow processing solves most of the problems associated to batch processing:
- Large productions can be achieved with small reactors (intensification)
- Production can be instantaneously adapted to needs
- Risks are minimized
- Waste is minimized
- Scale-up is straightforward
Which are the Advantages of Flow Techniques?
Flow techniques present a series of advantages that make them a very convenient alternative for the production of organic compounds:
- Faster mixing
- Increased heat transfer (avoids exotherms and runaway reactions)
- Reactions with temperature-dependent selectivity issues are more easily controlled
- Improved safety profile (even in the worst case, the reacting volumes are so small that possible damages are limited)
- Process intensification (reduced footprint, increased sustainability profile)
- Flexible production
- Facilitates optimization of reaction conditions (saving time and volume of reagents)
- Amenable for automation
ERTFLOW: your batch to flow partner!
We have detailed below a representative list of some of the reactions carried out in continuous flow in our lab:
- Aldol and cross-aldol reactions
- α-Aminoxylation of aldehydes and ketones
- Syn– and anti-Mannich reactions
- Three-component anti-Mannich reactions
- Michael additions
- Domino Michael-Knoevenagel reaction
- α-Amination of aldehydes
- Friedel-Crafts alkylation & aza-Friedel-Crafts reactions
- Allylic amination
- Alcohol oxydations
- Photoredox reactions
- Carbene transfer reactions