Summary of the technology
We are seeking licensees for the manufacture and commercialization of market-ready photoreactors with full control on temperature and light intensity. The developed photoreactors comprise several reaction spaces in order to allow parallel experimentation and reaction optimization.
Currently available batch-photochemical reactors in the market are limited and not adapted to the different emerging fields of chemical research and industry. For instance, the current commercial photo-reactors for synthetic scale from milligrams to few grams do not allow for a basic, simultaneous and simple control of the light-intensity and the temperature, which results in a poor reproducibility.This is even more problematic when high throughput experimental techniques (HTET) are used to accelerate the optimization of photocatalytic reactions. HTET is an extremely useful and successful approach to deal with reaction discovery and optimization processes, especially in photoredox catalysed transformations, where the number of variables to be optimized is usually large. For instance, catalyst, cocatalyst and substrate loadings, additives, solvent, temperature, light source and intensity, all influence the output and the catalytic performance, leading to a typical range volume of 1000 - 5000 experiments per study. This poor control over the reaction parameters slows down the research, innovation and the applicability and reproducibility of the newly developed synthetic methods between laboratories. The poor control over the reaction also renders the difficulty in the transferability to industry, in which tight control about the composition of synthesized products is mandatory.
We have developed two laboratory prototypes of photoreactors:
- Device for initial screening and optimization phase (milligrams, HTE-Milligram) t
- Device for synthetic applications (grams Multi-gram)
The Multi-Photo-Reactors will allow high degrees of reliability and reproducibility since they simultaneously control the two essential variables in photocatalytic transformations: i) temperature and ii) light-intensity.
The parallel photoreactor is typically formed by two independent BLOCKS (BLOCK-LED and BLOCK-REACTION) that works together and are separated by an insulating layer. The BLOCK-LED is formed by a LED array attached to a temperature control plate and connected to a regulable power source. The BLOCK-REACTION is mainly formed by a solid highly conductive with an internal refrigeration circuit to ensure a stable and correct temperature control of the reactions.
- Use of high intensity light possible
- Full temperature control
- adaptable reaction size
R&D in photochemistry, drug discovery, syntehtic tools, development of active ingredients
Intellectual property status
Patent already applied for
Current development status
Desired business relationship
Institute of Chemical Research of Catalonia
Technology Transfer Office