RAMOT at Tel Aviv University Ltd.

Molecular Electronics and Transistors based on Peptide Nanostructures

Posted by RAMOT at Tel Aviv University Ltd.Responsive · Innovative Products and Technologies · Israel

Summary of the technology

Proprietary peptide nanostructures can be readily fabricated on various surfaces including electrodes. A physical vapor deposition method (PVD) allows the precise control on the molecular dimensions of the structures using industry standard techniques. These nanostructures were used to fabricate metallic nanowires1 as well as trilayer metal-peptide-metal nano-cables. Electrodes and storages devices were modified with the peptide nanostructures. Recent work includes the application of the nanostructures to Ion-Sensitive Field-Effect Transistor (ISFET) with very strong responses measured, providing the basis for potential applications (to be published).
The chemical nature of the building blocks allows the simple modification with various recognition elements. This could be readily modified to recognize DNA bases for sequencing purposes.
The peptide structures are semi-conductive and possess various other unique physical properties (including mechanical rigidity, piezoelectric properties, non-linear optical properties, etc.).
Project ID : 7-2013-455

The Technology
Proprietary peptide nanostructures1 can be readily fabricated on various surfaces including electrodes2,4. A physical vapor deposition method (PVD) allows the precise control on the molecular dimensions of the structures using industry standard techniques. These nanostructures were used to fabricate metallic nanowires1 as well as trilayer metal-peptide-metal nano-cables3. Electrodes and storages devices were modified with the peptide nanostructures. Recent work includes the application of the nanostructures to Ion-Sensitive Field-Effect Transistor (ISFET) with very strong responses measured, providing the basis for potential applications (to be published).
The chemical nature of the building blocks allows the simple modification with various recognition elements. This could be readily modified to recognize DNA bases for sequencing purposes.
The peptide structures are semi-conductive5,6 and possess various other unique physical properties (including mechanical rigidity, piezoelectric properties, non-linear optical properties, etc.).

Stage of Development and Patents
The technology is extensive and there is a very strong IP portfolio exists which includes the nanostructures themselves, modifications of the building blocks, filling and coating of the structures, and deposition methods. Taken together, a method for ultrasensitive detection of biomolecules by the medication of electrodes is available. The patented novel technology is compatible with industry deposition methods and could be implemented into non-optical detection of DNA sequences.

Supporting Publications
1. Casting Metal Nanowires within Discrete Self-Assembled Peptide Nanotubes. Science 300, 625-627 (2003).
2. Controlled Patterning of Aligned Self-Assembled Peptide Nanotubes. Nature Nanotech.1, 195-200 (2006).
3. Fabrication of Coaxial Metal Nanowires Using Self-Assembled Peptide Nanotube Scaffold. Nano Lett. 6, 1594-1597 (2006).
4. Self-Assembled Arrays of Peptide Nanotubes by Vapour Deposition. Nature Nanotech. 4, 849-854 (2009).
5. Elementary Building Blocks of Self-Assembled Peptide Nanotubes. J. Am. Chem. Soc. 132, 15632-15636 (2010).
6. Peptides as Biological Semiconductors. Nature 468, 516–517 (2010).


Project manager

Rona Samler
VP, BD Physical Science, Medical Device, Chemistry

Project researchers

Judith Rishpon
T.A.U Tel Aviv University, Life Sciences
Molecular Microbiology-Biotechnology

Yosi Shacham- Diamand
T.A.U Tel Aviv University, Engineering
School of Electrical Engineering

Ehud Gazit
T.A.U Tel Aviv University, Life Sciences
Molecular Microbiology-Biotechnology

Related keywords

  • Biology / Biotechnology
  • Micro- and Nanotechnology related to Biological sciences
  • Medical Technology / Biomedical Engineering
  • Microbiology Technology
  • Cellular and Molecular Biology Technology
  • Bioinformatics Technology
  • Medicine, Human Health
  • Micro- and Nanotechnology
  • Nanotechnologies related to electronics & microelectronics
  • Micro and Nanotechnology related to Electronics and Microelectronics
  • Biological Nanomaterials
  • Electronics, Microelectronics
  • Electronic circuits, components and equipment
  • Microbiology Market
  • Micro- and Nanotechnology related to Biological sciences
  • Biochemistry / Biophysics Market
  • Stem cells and biobanks
  • Cellular and Molecular Biology Market
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  • Therapeutic
  • Clinical Medicine
  • Electronic Components
  • Electronics Related Equipment
  • Fibre Optics
  • Laser Related
  • Some other electronics related
  • Life Sciences and Biotechnology
  • Peptides / Proteins
  • Nanotechnology
  • Nano Materials
  • Nanotechnology
  • Nano Electronics
  • Nanotechnology
  • Nano Biotechnology
  • Electronics and Electro-Optics
  • Advanced Circuits
  • Material Sciences
  • Peptides /Proteins

About RAMOT at Tel Aviv University Ltd.

Technology Transfer Office from Israel

Ramot is Tel Aviv University's (TAU) technology transfer company and its liaison to industry, bringing promising scientific discoveries made at

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