RAMOT at Tel Aviv University Ltd.

Guided Regeneration Gel: A novel biocompatible hydrogel for peripheral nerve reconstruction and wound healing

Posted by RAMOT at Tel Aviv University Ltd.Responsive · Knowhow and Research output · Israel

Summary of the technology

Guided Regeneration Gel (GRG) is a novel biocompatible, biodegradable hydrogel for peripheral nerve reconstruction and wound healing. GRG, similar to the extracellular matrix (ECM), is transparent, highly viscous, malleable and adaptable to various shapes and formats. GRG is based on mixed-intercalated (for short time lasting effects) or cross-linked hyaluronic acid together with SOD and novel laminin bioactive peptides (for long lasting effects), serving together as guiding tracks for cell migration and regeneration. GRG can be used for ex-vivo or in-vivo tissue formation and for treatment of damaged or lost tissue.
Project ID : 2-2011-6

The Technology

Guided regeneration gel (GRG) is a novel biocompatible, biodegradable hydrogel for peripheral nerve reconstruction, cell therapy and wound healing. Similar to the extracellular matrix (ECM), GRG is transparent, highly viscous, malleable, and adaptable to various shapes and formats. GRG is made up of three components: hyaluronic acid, superoxide dismutase (SOD) and laminin-derived specific peptides; GRG can be formulated for a short-lasting effect (mixed-intercalated) or for long-lasting effects (cross-linked), serving together as guiding tracks for cell migration and regeneration.

The Need and Potential Application

GRG can be used for ex vivo or in vivo tissue formation and for treatment of damaged or lost tissue.
Stage of Development

Research to-date has shown that GRG:

  • Simulates cell growth, neuronal sprouting and ECM formation, supporting cells in vitro and in vivo upon implantation.
  • Supports 3D growth and differentiation of various cell types (embryonic, adult stem cells and preneuronal cells).
  • Induces growth of peripheral neurons that bridge massive peripheral nerve loss in rats (preliminary data). Extended in vivo studies are on-going.

The implications for therapeutic applications include peripheral nerves reconstruction, cell therapy, corneal preservation, wound healing, and as a post-irradiation tissue cavity filler.

Patents

PCT/IL2008/001120 (US: allowed; EP, CN, CA, IN, ISR: examination)

Project manager

Rona Samler
VP, BD Physical Science, Medical Device, Chemistry

Project researchers

Zvi, Emeritus Nevo
T.A.U Tel Aviv University, Medicine-Sackler Faculty
Clinical Biochemistry

Shimon Rochkind
Sourasky Medical center,

Related keywords

  • Medicine, Human Health
  • Medical Technology / Biomedical Engineering
  • Biology / Biotechnology
  • Cellular and Molecular Biology Technology
  • Microbiology Technology
  • Bioinformatics Technology
  • Micro- and Nanotechnology related to Biological sciences
  • Microbiology Market
  • Micro- and Nanotechnology related to Biological sciences
  • Biochemistry / Biophysics Market
  • Stem cells and biobanks
  • Cellular and Molecular Biology Market
  • Bioinformatics Market
  • Therapeutic
  • Clinical Medicine
  • Life Sciences and Biotechnology
  • Peptides / Proteins
  • Cell therapy
  • Pharmaceutical Indications
  • cns
  • Cell therapy
  • Pharmaceutical Indications
  • inflammation
  • Cell therapy

About RAMOT at Tel Aviv University Ltd.

Technology Transfer Office from Israel

Ramot is Tel Aviv University's (TAU) technology transfer company and its liaison to industry, bringing promising scientific discoveries made at

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