RAMOT at Tel Aviv University Ltd.

Improved Calcitonin-based Therapeutics

Posted by RAMOT at Tel Aviv University Ltd.Responsive · Innovative Products and Technologies · Israel

Summary of the technology

The aggregation site on human calcitonin has been identified, paving the way for development of specific inhibitors of calcitonin amyloid fibril formation. Such inhibitors will enable development of improved calcitonin therapeutics as well as greatly facilitate in vitro calcitonin manipulations.
Project ID : 10-2007-103

Technology
The aggregation site on human calcitonin has been identified, paving the way for development of specific inhibitors of calcitonin amyloid fibril formation. Such inhibitors will enable development of improved calcitonin therapeutics as well as greatly facilitate in vitro calcitonin manipulations.

The Need
The therapeutic use of human calcitonin is severely limited by its tendency to associate and form fibrils. Salmon calcitonin, which is used in the clinic, causes immunogenic reactions in some treated patients owing to low sequence homology compared to the human form. There is thus a clear need for a calcitonin based therapeutic which is non-immunogenic and does not associate to form fibrils.

Potential Applications
Calcitonin therapy for:

  • Osteoporosis therapy
  • Paget's disease
  • In vitro calcitonin solubilizer

Stage of development
Short peptide inhibitors of human calcitonin aggregation have been synthesized characterized and tested in vitro.

Project manager

Elisha Natan
Director BD

Project researchers

Ehud Gazit
T.A.U Tel Aviv University, Life Sciences
Molecular Microbiology-Biotechnology

Related keywords

  • Medicine, Human Health
  • Medical Technology / Biomedical Engineering
  • Biology / Biotechnology
  • Cellular and Molecular Biology Technology
  • Microbiology Technology
  • Bioinformatics Technology
  • Micro- and Nanotechnology related to Biological sciences
  • Microbiology Market
  • Micro- and Nanotechnology related to Biological sciences
  • Biochemistry / Biophysics Market
  • Stem cells and biobanks
  • Cellular and Molecular Biology Market
  • Bioinformatics Market
  • Therapeutic
  • Clinical Medicine
  • Life Sciences and Biotechnology
  • Peptides / Proteins
  • Pharmaceutical Indications
  • inflammation

About RAMOT at Tel Aviv University Ltd.

Technology Transfer Office from Israel

Ramot is Tel Aviv University's (TAU) technology transfer company and its liaison to industry, bringing promising scientific discoveries made at

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