RAMOT at Tel Aviv University Ltd.

Novel Anti Bacterial Drug

Posted by RAMOT at Tel Aviv University Ltd.Responsive · Innovative Products and Technologies · Israel

Summary of the technology

Two non-toxic short peptides were conjugated to form a novel drug candidate. One of the peptides is a polymyxin-B or polymyxin-E analog (PMBN or PMEN, respectively) while the other is an immune cell chemotactic peptide (fMLF). The resultant new drug candidates (PMBN-fMLF or PMEN-fMLF) exhibit three antimicrobial activities: (a) it binds specifically to gram negative bacteria, thus enhancing penetration of antibiotics into the bacteria and (b) it promotes bacterial killing by blood phagocytes and (c) It binds to free LPS in the blood thus reduces effect on patients.
Project ID : 10-2007-98

Technology

Two non-toxic short peptides were conjugated to form a novel drug candidate. One of the peptides is a polymyxin-B or polymyxin-E analog (PMBN or PMEN, respectively) while the other is an immune cell chemotactic peptide (fMLF). The resultant new drug candidates (PMBN-fMLF or PMEN-fMLF) exhibit three antimicrobial activities: (a) it binds specifically to gram negative bacteria, thus enhancing penetration of antibiotics into the bacteria and (b) it promotes bacterial killing by blood phagocytes and (c) It binds to free LPS in the blood thus reduces effect on patients.

The Need

Bacteremic infections (when bacteria enter the blood stream), caused by bacteria and by Gram-negative bacilli in particular, constitute one of the major infectious disease problems in modern medicine. Antibiotic treatment is often administered too late, usually when symptoms appear, and before bacterial sensitivity to antibiotics is determined. The mortality rate due to bacterial septicemia is thus very high.

Advantages

Rapid and effective destruction of bacteria via dual complementary killing mechanisms.

Development of resistance is not anticipated owing to it's novel mode of action.

Applications

Co –administration with antibiotics in the Treatment of septicemia and bacteremia and possibly in the treatment of other Gram Negative infections.

Stage of Development

PMBN-fMLF was found to be active on a large number of clinical isolates. In vivo experiments in mice showed protection against Klebsiella pneumoniae following treatment with the drug. LD50 value of PMBN-fMLF is ~3 fold lower than polymyxin-B.

PMEN-fMLF exhibited potent in vitro and in-vivo anti-bacterial activity with a ~10 fold decrease in LD50, when compared to polymyxin-E.

Patent status

Granted US (7,435,716) & EU (EP 1 351 992) (DE, FR, UK)


Project manager

Elisha Natan
Director BD

Project researchers

Itzhak Ofek
T.A.U Tel Aviv University, Medicine-Sackler Faculty
Clinical Microbiology and Immunology

Matityahu Fridkin
Weizmann Institute of Science (WIS),

Related keywords

  • Medicine, Human Health
  • Medical Technology / Biomedical Engineering
  • Biology / Biotechnology
  • Cellular and Molecular Biology Technology
  • Microbiology Technology
  • Bioinformatics Technology
  • Micro- and Nanotechnology related to Biological sciences
  • Microbiology Market
  • Micro- and Nanotechnology related to Biological sciences
  • Biochemistry / Biophysics Market
  • Stem cells and biobanks
  • Cellular and Molecular Biology Market
  • Bioinformatics Market
  • Therapeutic
  • Clinical Medicine
  • Life Sciences and Biotechnology
  • Peptides / Proteins
  • Pharmaceuticals Indications
  • Infection Diseases

About RAMOT at Tel Aviv University Ltd.

Technology Transfer Office from Israel

Ramot is Tel Aviv University's (TAU) technology transfer company and its liaison to industry, bringing promising scientific discoveries made at

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