Centre Technology Transfer CITTRU

Manganese-lactoferrin complex stimulating the growth of probiotic bacteria

Posted by Centre Technology Transfer CITTRUResponsive · Patents for licensing · Germany

Summary of the technology

The subject of the offer is manganese-lactoferrin complex with properties stimulating the growth of probiotic bacteria in digestive system. Possible applications of the invention include prevention and treatment of bacterial infections (including sepsis in newborns), chronic inflammatory bowel diseases, dietary supplementation in prevention of bacterial infections and some other indications.

Manganese-lactoferrin complex.pdf [PDF]

New and innovative aspects

The present invention, lactoferrin saturated with manganese, is distinguished by unique property of stimulating the growth of probiotic bacterial strains in gastrointestinal tract. These bacterial strains are part of the natural, beneficial bacterial flora of human.

Main advantages of its use

Currently on the market there are many lactoferrin preparations. The distinguishing features of the invention as compared to other formulations are:

  • distinct stimulatory effect on growth of the probiotic Lactobacillus bacteria;
  • the possibility to saturate the complex exclusively with particularly advantageous and safe manganese on the third oxidation state;
  • absence of ferric ions indispensable for growth of pathogenic bacteria and preserved ability of the complex to uptake ferric ions after release of manganese in the gastrointestinal tract;
  • high absorption of manganese and its gradual release in the human body, resulting in increased safety.
  • The invention in addition to stimulatory effect on growth of probiotic bacteria colonies retains all beneficial features of commercially available preparations of lactoferrin.


Lactoferrin is a protein with known antibacterial, antifungal and antiviral properties. Due to these properties, lactoferrin is widely used among others as compound of functional foods, dietary supplements or various types of pharmaceuticals. Specific use of lactoferrin was found in the prevention of infections in premature infants, newborns and older children. Oral supplementation with various forms of lactoferrin is important in reducing inflammation by neutralization of bacterial antigens (including LPS) and preventing the passage of bacteria from the intestinal lumen into the bloodstream that can cause sepsis in infants with very low birth weight.


  • prevention of neonatal infections (including prematures with low birth weight particularly vulnerable to infections) allowing to maintain or restore normal bacterial flora – reduction the risk of newborn infections leading to sepsis;

  • prevention and treatment of chronic inflammatory bowel diseases;

  • dietary supplement used in the prevention and/or treatment of bacterial and viral infections;
  • preparation supporting the treatment of patients on antibiotic therapy, cancer patients and those suffering from chronic intestinal inflammation.

Intellectual property status

The invention is subject to Polish patent application covering the formulation, method of its manufacture and use. Priority date for the invention is September 2015 with PCT patent application deadline in September 2016. Extending patent protection in national phase is expected in 2018.

Current development status

Further research is conducted at the Faculty of Chemistry, Jagiellonian University and the Faculty of Pharmacy, Jagiellonian University Medical College

Desired business relationship

Currently the Centre for Technology Transfer CITTRU is looking for entities interested in licensing and commercial application of described invention. Cooperation with partners interested in joint R&D projects in scientific topic related to the invention is also desirable

Related keywords

  • Pharmaceutical Products / Drugs
  • Medical Research
  • Microbiology Technology
  • Technologies for the food industry
  • Food Additives/Ingredients/Functional Food
  • Food Technology
  • Medicine, Human Health
  • Care, Hygiene, Beauty, Cosmetics
  • Therapeutic
  • Other Medical/Health Related
  • Agro and Marine biotech
  • Health food
  • Dairy Products
  • Ices and Desserts
  • Pharmaceuticals/fine chemicals
  • Health and beautty aids, Cosmetics
  • Oncology
  • lactoferrin
  • sepsis
  • inflammation
  • probiotics
  • bacteria
  • manganese

About Centre Technology Transfer CITTRU

Technology Transfer Office from Germany

Centre for Technology Transfer CITTRU is a part of Jagiellonian University, whose role is to promote university research, to support innovation and to create cooperation with the business. CITTRU main task is to offer the scientific achievements of the Jagiellonian University in the market by providing legal protection, licensing, sale of intellectual property rights, creation of academic business, coordination of company-ordered research projects, etc. Currently promoted technologies are mainly focused on new materials science, chemistry, pharma and medical technology.

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