Summary of the technology
The subject of the offer is manganese-lactoferrin complex with properties stimulating the growth of probiotic bacteria in digestive system. Possible applications of the invention include prevention and treatment of bacterial infections (including sepsis in newborns), chronic inflammatory bowel diseases, dietary supplementation in prevention of bacterial infections and some other indications.
New and innovative aspects
The present invention, lactoferrin saturated with manganese, is distinguished by unique property of stimulating the growth of probiotic bacterial strains in gastrointestinal tract. These bacterial strains are part of the natural, beneficial bacterial flora of human.
Main advantages of its use
Currently on the market there are many lactoferrin preparations. The distinguishing features of the invention as compared to other formulations are:
- distinct stimulatory effect on growth of the probiotic Lactobacillus bacteria;
- the possibility to saturate the complex exclusively with particularly advantageous and safe manganese on the third oxidation state;
- absence of ferric ions indispensable for growth of pathogenic bacteria and preserved ability of the complex to uptake ferric ions after release of manganese in the gastrointestinal tract;
- high absorption of manganese and its gradual release in the human body, resulting in increased safety.
- The invention in addition to stimulatory effect on growth of probiotic bacteria colonies retains all beneficial features of commercially available preparations of lactoferrin.
Lactoferrin is a protein with known antibacterial, antifungal and antiviral properties. Due to these properties, lactoferrin is widely used among others as compound of functional foods, dietary supplements or various types of pharmaceuticals. Specific use of lactoferrin was found in the prevention of infections in premature infants, newborns and older children. Oral supplementation with various forms of lactoferrin is important in reducing inflammation by neutralization of bacterial antigens (including LPS) and preventing the passage of bacteria from the intestinal lumen into the bloodstream that can cause sepsis in infants with very low birth weight.
prevention of neonatal infections (including prematures with low birth weight particularly vulnerable to infections) allowing to maintain or restore normal bacterial flora – reduction the risk of newborn infections leading to sepsis;
prevention and treatment of chronic inflammatory bowel diseases;
- dietary supplement used in the prevention and/or treatment of bacterial and viral infections;
- preparation supporting the treatment of patients on antibiotic therapy, cancer patients and those suffering from chronic intestinal inflammation.
Intellectual property status
The invention is subject to Polish patent application covering the formulation, method of its manufacture and use. Priority date for the invention is September 2015 with PCT patent application deadline in September 2016. Extending patent protection in national phase is expected in 2018.
Current development status
Further research is conducted at the Faculty of Chemistry, Jagiellonian University and the Faculty of Pharmacy, Jagiellonian University Medical College
Desired business relationship
Currently the Centre for Technology Transfer CITTRU is looking for entities interested in licensing and commercial application of described invention. Cooperation with partners interested in joint R&D projects in scientific topic related to the invention is also desirable
About Centre Technology Transfer CITTRU
Technology Transfer Office from PolandCentre Technology Transfer CITTRU
Centre for Innovation, Technology Transfer and University Development (CITTRU) is a part of Jagiellonian University, whose role is to promote university research, to support innovation and to create cooperation with the business. CITTRU main task is to offer the scientific achievements of the Jagiellonian University in the market by providing legal protection, licensing, sale of intellectual property rights, creation of academic business, coordination of company-ordered research projects, etc. Currently promoted technologies are mainly focused on new materials science, pharmacology and medical technology. Inventions offered by Jagiellonian University are promoted and awarded during numerous exhibitions, e.g. 58th International Exhibition of Innovation, Research and New Technologies INNOVA (BRUSSELS 2009), 38th International Exhibition of Invention New Techniques & Products (Geneva 2010) or 24th International exhibition of environmental equipment, technologies and services POLLUTEC (Paris 2009).