The technology relates to hydroxypheophorbide compounds with bioactivity towards obesity and obesity-related co-morbidities. The compound may be used in the therapy or treatment of obesity, an obesity-related disorder, an obesity related disease, being overweight, an obesity-related condition, or lipid obesity disorders.
Obesity is an increasing epidemic, associated with several chronic diseases like diabetes, cardiovascular diseases, and cancer. There is an urgent need for effective lipid-reducing treatments.
Current therapeutic options present several limitations, such as severe side effects and challenges in long-term adherence. Some natural products are already being used in the clinic as anti-obesogenic compounds.
132-hydroxypheophorbide (hpa) compounds are promising candidates for treating obesity and related co-morbidities. These compounds are derived from chlorophyll, already known for its beneficial bioactivities.
Hpa has demonstrated novel and significant lipid-reducing activity, evaluated using the zebrafish Nile red fat metabolism assay and a 3D cell culture model of murine pre-adipocytes. The compounds can be used in therapy or treatment of obesity, overweight and related disorders. The compound can be obtained from natural resources, such as Spirulina, a GRAS cyanobacteria.
Current development status
Experimental technologies
Applications
Nutraceuticals
Food Supplements
Pharmaceuticals
Desired business relationship
Technology selling
Patent licensing
Technology development
CIIMAR - Interdisciplinary Centre of Marine and Environmental Research - is a leading research and advanced training institution of the University of Porto, working at the frontier of Ocean Knowledge and Innovation.
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