This technology relates to novel halogenated fatty acid lactylates, in particular chlorinated fatty acid lactylates compounds, isolated from the cyanobacterial strain Sphaerospermopsis sp. LEGE 00249, with antimicrobial and antibiofilm activity towards healthcare-associated microbial infections.
Healthcare-associated infections are the most frequent adverse cases in the healthcare settings worldwide, namely the biofilm-associated microbial infections related to medical devices. Staphylococcus aureus and coagulase negative staphylococci are the most frequent pathogens found in those cases. Biofilm infections are difficult to overcome solely by using antibiotics, mainly due to inherent antibiotic resistance.
This technology relates to novel halogenated fatty acid lactylates, in particular chlorinated fatty acid lactylates compounds, isolated from the cyanobacterial strain Sphaerospermopsis sp. LEGE 00249, with antimicrobial and antibiofilm activity towards healthcare-associated microbial infections. These halogenated fatty acid lactylates, present antibacterial activity against Staphylococcus aureus and antibiofilm activity against coagulase-negative staphylococci (CNS). The compounds can be used in medicine with potential applications in the treatment and prevention of biofilm-associated infections.
Advantages:
• Natural product with potential biodegradable properties;
• Antimicrobial activity against Staphylococcus aureus;
• Antibiofilm activity against coagulase-negative staphylococci;
• No toxicity.
Current development status
Experimental technologies
Applications
Pharmaceutical; Treatment and prevention of bacterial infections; Coatings for medical devices; Veterinary.
Desired business relationship
Technology selling
Patent licensing
Technology development
CIIMAR - Interdisciplinary Centre of Marine and Environmental Research - is a leading research and advanced training institution of the University of Porto, working at the frontier of Ocean Knowledge and Innovation.
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