This invention introduces atropisomeric 1,8-bisphenol naphthalenes and their derivatives, which are designed for enantioselective recognition and asymmetric synthesis. Chiral drugs, which are compounds that exist in two mirror-image forms (enantiomers), account for over half of all medications currently in use. These enantiomers can exhibit significantly different biological activities, making the ability to separate and utilize the active form crucial for effective treatment. The new compounds developed through this invention can resolve enantiomers and facilitate the synthesis of chiral drugs, enhancing their effectiveness and safety. For example, these compounds can be applied in the development of chiral catalysts or sensors, improving the efficiency of chemical reactions that require specific stereochemistry.
BACKGROUND
The field of asymmetric synthesis is crucial for producing chiral compounds used in pharmaceuticals and other applications. Traditional methods often struggle with the resolution of enantiomers due to rapid racemization. This invention addresses these challenges by providing stable 1,8-bisphenol naphthalene derivatives that can be isolated and utilized in various chemical processes, including drug discovery and molecular recognition.
Benefit
Market Application
Intellectual property status
Granted Patent
Patent number : Patent No. 9,085,511
Where : USA
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