Seeking Compounds to act on the TRPA1 ‘cough’ receptor

  • Strategic Allies Ltd.
  • From United Kingdom
  • Responsive
  • Project Size Range : 50,000 - 250,000 €
  • Deadline completed
    The submission process for new proposals is closed. Proposals submitted before the deadline will follow the standard evaluation process.

Desired outcome

We are working with a manufacturing company that uses a range of flavours to complement and mask active ingredients in their products. Consumers are increasingly keen to experience new flavours and are open to more unusual combinations and stronger, stimulating flavours (e.g., wasabi). However, some ingredients can trigger a burning sensation and a need to cough, both of which are unwelcome side effects of consuming such compounds. In addition, active ingredients such as cannabis (CBD) may trigger a similarly unpleasant sensation in the mouth / throat. The client has identified the TRPA1 receptor as being primarily responsible for these responses, and wishes to identify solutions to prevent or mitigate these side-effects.

Details of the Innovation Need

The client is actively searching for food-grade solutions to mask, remove or modulate the effects of activating the TRPA1 receptor in the oral cavity. Potential solutions could come from (but are not limited to) the following: -


  • Food and beverages (alcoholic and non-alcoholic products);
  • Pharmaceuticals;
  • Nutraceuticals


Physical masking, biochemical masking and functional taste masking

  • Compounds to act directly / indirectly as TRPA1 channel antagonist or modulator
  • Compounds to act directly / indirectly as TRPA1 agonist or analgesic
  • Compounds used in cough medicine as cough suppressant
  • Encapsulation (nano- and micro-) technologies for compounds


May include umami flavourants, botanical extracts, pure compounds

NB - No interest in the use of sweeteners to mask.

The client is interested in any product format (e.g. powder, emulsion, liquid, etc) or development stage solutions providing proof of concept can be demonstrated.

The client is a large and well established business with excellent market access. They are searching for companies developing and supplying solutions to meet their current and future products, and so this represents an excellent business opportunity for a new and ongoing supplier relationship

Related Keywords

  • Food Additives/Ingredients/Functional Food
  • Agriculture and Marine Resources
  • Agriculture
  • Agrofood Industry
  • Technologies for the food industry
  • encapsulation
  • taste masking

About Strategic Allies Ltd.

Open Innovation Consultancy Company searching on behalf of multi-national, manufacturing clients.

Strategic Allies Ltd.

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