A method for the preparation of hydrogels suitable for producing artificial tissues has been developed. The method combines fibrin, fibrinogen and short-chained peptides, which interact to enhance cell adhesion and proliferation. The resulting tissues could be used as a medicine for organ regeneration, and could restore the functional activity of a damaged or diseased organ.
Tissue engineering focuses on the development of strategies to replace, repair, maintain and/or improve biological tissues. There are three different approaches: the exclusive use of cells; the exclusive use of polymeric matrices; or the combination of both cells and polymeric matrices.
The extracellular matrix plays an essential role since it provides the necessary support for cell proliferation and the maintenance of cell functions. An ideal matrix should be three-dimensional and highly porous; with a surface of appropriate chemical properties to allow cell adhesion, proliferation and differentiation; and with adequate biomechanical properties for the native tissue intended to replace.
Materials currently used to generate the polymeric matrix are biocompatible, biodegradable and provide suitable physiological conditions for cell adhesion and proliferation. However, they all have a lack of well-organized and controlled internal structure, they are biomechanically weak, and rapidly degraded in vivo. In addition, it is hard to balance their mechanical properties and porosity.
In this invention, a new method for the preparation of a hydrogel suitable for the production of artificial tissues has been developed. It consists of the combination of fibrin and fibrinogen with short-chain peptides, in a way that their interactions lead to a more appropriate internal structure compared to current solutions. While showing a high biocompatibility, the resulting material improves the biomechanical properties and the porosity, and enhances cell adhesion and the proliferation of the tissue to be regenerated.
ADVANTAGES AND BENEFITS
Current development status
Laboratory prototypes
Applications
Health
Tissue engineering
Regenerative medicine
Biomedicine
Biotechnology
Desired business relationship
Patent licensing
Granada University is one of the most important universities of Spain. The main goal is to transfer technology that our research groups, more than 500, are developing to the industries and companies which are able to take profit from them. It is a general University so Research and Development are offered in different fields like Health Science and Technology, Physics, Chemistry and Mathematics, Environment and Natural Resources, Biotechnology, Information and Communication Technologies, Social, Economic and Legal Sciences....
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