Green Chemistry for Ketones and Aldehydes Production

  • Yeda
  • From Israel
  • Responsive
  • Patents for licensing

Summary of the technology

Our technology provides a new type of oxidative cleavage reaction of organic compounds with highly selective
product formation.
Polyoxometalate (POM) catalysts have become well-known for their utility and diversity in specific reactions.
Through the elucidation of POM catalytic pathways, greater versatility has been achieved. This technology is one
such application of a novel POM catalyst and is exploited to cleave carbon-carbon double bonds in alkenes
(olefins) through an aerobic oxidation reaction. Oxidation reactions are of particular interest because they are
difficult to achieve on an industrial scale while maintaining “green” chemistry practices.


The Need

The realization that many processes practiced on a large scale were detrimental to the environment led to a movement of reshaping the science of organic chemistry. Many of the reactions most problematic to the environment are in the area of oxidation chemistry. Obtaining viable “green” synthetic procedures requires new catalysts capable of activation of oxidants that will lead to new selective transformations. As such, much of the research in selective oxidation is in the development of new catalysts, for example those that use inorganic POMs as their reactive core.
The use of POM catalysts has presented many new opportunities not typical of oxidative chemical reactions. More specifically, the use of POMs with environmentally benign oxygen donors, like molecular oxygen (O2) or nitrous oxide (N2O), has produced methods for efficient and selective reactions that fulfill the requirements of green chemistry.
An enticing application utilizing these methods is with renewable resources such as unsaturated fatty acid derivatives as feedstock for oxidation reactions. This application of green chemistry could attack two areas, environmentally friendly catalysts and renewable feedstock, and could be a revolutionary push in industrial organic chemistry towards safe, sustainable, and ecologically conscious processing.

The Solution

Novel POM catalyst which achieves aerobic carbon-carbon bond cleavage of alkenes:
Use renewable resources as feedstock

Highly selectable products

Technology Essence
Our approach is motivated by societal considerations that demand environmentally benign and sustainable solutions for oxidative reactions. As such, we have developed a scheme to react NO2 with a transition-metalsubstituted POM which yields a metal-nitro intermediate that is competent for forming the precursors for oxidation with molecular oxygen, O2, to have a final product of ketones and/or aldehydes, and regenerate the POM catalysts.
This method has preference towards di/tri-substituted alkenes. High yields of ketones or aldehydes have been produced and the POM catalyst is regenerated without further oxidation to carboxylic acids, as is typical with other oxidative catalysts.
The selective cleavage of carbon-carbon double or triple bonds with metal-nitro or metal-nitrito compound has not been reported. This exciting new discovery could lead to a wide variety of organic reactions not previously possible, along with revolutionary green oxidative chemistry techniques.

Applications and Advantages


  • Environmentally friendly oxidation reaction

Easy catalyst regeneration

As a novel catalyst in industrial organic chemistry processes
Sold as a stand-alone catalyst for laboratory or individual use

Development Status

Further research will provide additional product selectivity and will focus on the oxidation of terminal alkenes and more control of reaction selectivity, for example, epoxidation versus carbon-carbon bond cleavage. This will provide further versatility of an already flexible catalyst.

Market Opportunity

The market potential for this technology is largely driven by government regulations and the societal desire for greener processes in industry.
According to the first market research report on POM catalysts by QYResearch, “Global POM Industry Report,” POM catalysts have the potential lead the next generation of industrial organic chemistry techniques. A market closely aligned with implementing POMs for green organic chemistry solutions is the flavors and fragrances industry, and according to the report “Global Flavors and Fragrances Market 2014-2018,” by ReportBuyer, the industry is expected to grow at a CAGR of 5.63% during this period.

Intellectual property status

  • Granted Patent
  • Patent application number :USA Granted: 9,815,757

Related Keywords

  • Chemistry
  • Organic Chemistry
  • Micro- and Nanotechnology
  • Biological Sciences
  • Clean Production / Green Technologies
  • research

About Yeda

Yeda ("Knowledge" in Hebrew) Research and Development Company Ltd. is the commercial arm of the Weizmann Institute of Science (WIS) and is the second company of its kind established in the world.

WIS is one of the world’s leading multidisciplinary basic research institutions in the natural and exact sciences. It is located in Rehovot, Israel, just south of Tel Aviv. It was initially established as the Daniel Sieff Institute in 1934, by Israel and Rebecca Sieff of London in memory of their son Daniel. In 1949, it was renamed for Dr. Chaim Weizmann, the first President of the State of Israel and Founder of the Institute.

Yeda initiates and promotes the transfer to the global marketplace of research findings and innovative technologies developed by WIS scientists. Yeda holds an exclusive agreement with WIS to market and commercialize its intellectual property and generate income to support further research and education.

Since 1959 Yeda has generated the highest income per researcher compared to any other TTO worldwide. Weizmann has generated a number of groundbreaking therapies, such as Copaxone, Rebif, Tookad, Erbitux, Vectibix, Protrazza, Humira, and recently the CAR-T cancer therapy Yescarta.

Yeda performs the following activities:

◣ Identifies and assesses research projects with commercial potential.
◣ Protects the intellectual property of WIS and its scientists.
◣ Licenses WIS' inventions and technologies to industry.
◣ Establishes new Startup companies based in WIS Intellectual Property
◣ Channels funding from industry to research projects.

Our portfolio covers a broad spectrum of the natural sciences, including:

◣ Agriculture and Plant Genetics, including Bio-fuels
◣ Chemistry and Nanotechnology
◣ Environmental Sciences and Solar Energy
◣ Mathematics and Computer Science
◣ Medical Devices
◣ Pharmaceuticals and Diagnostics
◣ Physics and Electro-Optics
◣ Research Tools


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