Protein disulphide isomerase inhibitors

Summary of the technology

Protein disulphide isomerase (PDI) family is a group of enzymes regulating endoplasmic reticulum protein. In addition to well-known role of PDI as molecular chaperones, their cell-surface disulfide exchange activity controls thrombosis, cancer cell adhesion, metastasis and vascular function. Thus, protein disulphide isomerase seems to be an interesting therapeutic target to be exploited to afford anti-thrombotic, anti-metastatic and vasoprotective action.


anti-thrombotic; anti-coagulant; anti-metastatic; vasoprotective

Desired business relationship

Technology selling

Patent licensing

Technology development

Intellectual property status

  • Patent already applied for
  • Patent application number :PCT/PL2020/050004

Attached documents

Related Keywords

  • Protein Engineering
  • Medical Health related
  • Therapeutic
  • Clinical Medicine
  • Oncology
  • Cardiology
  • Enzymology/Protein Engineering/Fermentation
  • inhibitors

About Jagiellonian University

Jagiellonian University, founded 1364, is the oldest university in Poland and one of the oldest worldwide. The research and teaching activities are conducted at 15 faculties, including the Medical College (Collegium Medicum). Over 3,700 researchers work at the university and the total number of students is about 50,000.

Maciej Lojewski

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